NDLI: Rhodopsin-regulated Insulin Receptor Signaling Pathway in Rod Photoreceptor Neurons

Content Provider	Springer Nature Link
Author	Rajala, Raju V. S. Anderson, Robert E.
Copyright Year	2010
Abstract	The retina is an integral part of the central nervous system and retinal cells are known to express insulin receptors (IR), although their function is not known. This article describes recent studies that link the photoactivation of rhodopsin to tyrosine phosphorylation of the IR and subsequent activation of phosphoinositide 3-kinase, a neuron survival factor. Our studies suggest that the physiological role of this process is to provide neuroprotection of the retina against light damage by activating proteins that protect against stress-induced apoptosis. We focus mainly on our recently identified regulation of the IR pathway through the G-protein-coupled receptor rhodopsin. Various mutant and knockout proteins of phototransduction cascade have been used to study the light-induced activation of the retinal IR. Our studies suggest that rhodopsin may have additional previously uncharacterized signaling functions in photoreceptors.
Starting Page	39
Ending Page	47
Page Count	9
File Format	PDF
ISSN	08937648
Journal	Molecular Neurobiology
Volume Number	42
Issue Number	1
e-ISSN	15591182
Language	English
Publisher	Humana Press Inc
Publisher Date	2010-04-21
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Insulin receptor Photobleaching Rhodopsin Phosphoinositdie 3-kinase Retina Rod outer segments Neurology Cell Biology Neurobiology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neurology Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Rhodopsin-Regulated Insulin Receptor Signaling Pathway in Rod Photoreceptor Neurons

Phosphoinositides and Photoreceptors

Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration

LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor

Insulin Growth Factor 1 Receptor/PI3K/AKT Survival Pathway in Outer Segment Membranes of Rod Photoreceptors

Expression and Localization of Connexins in the Outer Retina of the Mouse

Light-Dependent Compartmentalization of Transducin in Rod Photoreceptors

Adaptation of Mammalian Photoreceptors to Background Light: Putative Role for Direct Modulation of Phosphodiesterase

Are Rod Outer Segment ATP-ase and ATP-Synthase Activity Expression of the Same Protein?

Rhodopsin-regulated Insulin Receptor Signaling Pathway in Rod Photoreceptor Neurons

Similar Documents

Rhodopsin-Regulated Insulin Receptor Signaling Pathway in Rod Photoreceptor Neurons

Phosphoinositides and Photoreceptors

Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration

LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor

Insulin Growth Factor 1 Receptor/PI3K/AKT Survival Pathway in Outer Segment Membranes of Rod Photoreceptors

Expression and Localization of Connexins in the Outer Retina of the Mouse

Light-Dependent Compartmentalization of Transducin in Rod Photoreceptors

Adaptation of Mammalian Photoreceptors to Background Light: Putative Role for Direct Modulation of Phosphodiesterase

Are Rod Outer Segment ATP-ase and ATP-Synthase Activity Expression of the Same Protein?

Rhodopsin-regulated Insulin Receptor Signaling Pathway in Rod Photoreceptor Neurons