NDLI: Maternal Thyroxine Levels During Pregnancy and Outcomes of Cognitive Development in Children

Content Provider	Springer Nature Link
Author	Wang, Pingping Gao, Jian Zhao, Shihua Guo, Yong Wang, Zengfang Qi, Feng
Copyright Year	2015
Abstract	Though there were many studies assessing the relationship between maternal thyroxine levels during pregnancy and cognitive development in children, there was still lack of evidence for the association from a comprehensive assessment of published data. To get a more comprehensive estimate of the influence of low maternal thyroxine levels on cognitive function, a meta-analysis of prospective cohort studies was performed. Two electronic databases, MEDLINE and EMBASE, were searched for relevant prospective cohort studies. Relative risks (RR) with 95 % confidence intervals (95 % CI) were pooled using random-effect model of meta-analysis to assess the risk of delayed cognitive development in children. Seven prospective cohort studies with a total of 8273 mother-child pairs were included into the meta-analysis. There was obvious between-study heterogeneity in the meta-analysis (I $^{2}$ = 69.6 %). Meta-analysis of using random-effect model showed that low maternal thyroxine level was significantly associated with a threefold risk of delayed cognitive development in children (random RR = 3.08, 95 % CI 1.83–5.18, P < 0.001). When excluding the study with largest weight, there was no obvious between-study heterogeneity in the left studies (I $^{2}$ = 47.6 %), and meta-analysis using random-effect model showed that low maternal thyroxine level was still significantly associated with increased risk of delayed cognitive development in children (random RR = 3.76, 95 % CI 2.14–6.58, P < 0.001). Sensitivity analysis by omitting other studies by turns showed that there was no obvious change in the pooled risk estimates, and all pooled RRs were statistically significant. Therefore, the findings from the meta-analysis provide strong evidence for the association between maternal thyroxine levels during pregnancy and cognitive development in children. Low maternal thyroxine level is significantly associated with a threefold risk of delayed cognitive development in children.
Starting Page	2241
Ending Page	2248
Page Count	8
File Format	PDF
ISSN	08937648
Journal	Molecular Neurobiology
Volume Number	53
Issue Number	4
e-ISSN	15591182
Language	English
Publisher	Springer US
Publisher Date	2015-05-12
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Thyroxine levels Cognitive function Brain development Neurosciences Neurobiology Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Neurology Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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