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Ca$_{v}$1.3 and BK Channels for Timing and Regulating Cell Firing

Content Provider	Springer Nature Link
Author	Vandael, David Henry Marcantoni, Andrea Mahapatra, Satyajit Caro, Anton Ruth, Peter Zuccotti, Annalisa Knipper, Marlies Carbone, Emilio
Copyright Year	2010
Abstract	L-type Ca$^{2+}$ channels (LTCCs, Ca$_{v}$1) open readily during membrane depolarization and allow Ca$^{2+}$ to enter the cell. In this way, LTCCs regulate cell excitability and trigger a variety of Ca$^{2+}$-dependent physiological processes such as: excitation–contraction coupling in muscle cells, gene expression, synaptic plasticity, neuronal differentiation, hormone secretion, and pacemaker activity in heart, neurons, and endocrine cells. Among the two major isoforms of LTCCs expressed in excitable tissues (Ca$_{v}$1.2 and Ca$_{v}$1.3), Ca$_{v}$1.3 appears suitable for supporting a pacemaker current in spontaneously firing cells. It has steep voltage dependence and low threshold of activation and inactivates slowly. Using Ca$_{v}$1.3$^{−/−}$ KO mice and membrane current recording techniques such as the dynamic and the action potential clamp, it has been possible to resolve the time course of Ca$_{v}$1.3 pacemaker currents that regulate the spontaneous firing of dopaminergic neurons and adrenal chromaffin cells. In several cell types, Ca$_{v}$1.3 is selectively coupled to BK channels within membrane nanodomains and controls both the firing frequency and the action potential repolarization phase. Here we review the most critical aspects of Ca$_{v}$1.3 channel gating and its coupling to large conductance BK channels recently discovered in spontaneously firing neurons and neuroendocrine cells with the aim of furnishing a converging view of the role that these two channel types play in the regulation of cell excitability.
Starting Page	185
Ending Page	198
Page Count	14
File Format	PDF
ISSN	08937648
Journal	Molecular Neurobiology
Volume Number	42
Issue Number	3
e-ISSN	15591182
Language	English
Publisher	Humana Press Inc
Publisher Date	2010-11-20
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	L-type calcium channels Pacemaking currents Action potential firing Neurons Chromaffin cells Neurology Cell Biology Neurobiology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neurology Cellular and Molecular Neuroscience

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Ca$_{v}$1.3 and BK Channels for Timing and Regulating Cell Firing

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Ca$_{v}$1.3 and BK Channels for Timing and Regulating Cell Firing