NDLI: Wnt Signaling through the Ror Receptor in the Nervous System

Content Provider	Springer Nature Link
Author	Petrova, Iveta M. Malessy, Martijn J. Verhaagen, Joost Fradkin, Lee G. ordermeer, Jasprina N.
Copyright Year	2013
Abstract	The receptor tyrosine kinase-like orphan receptor (Ror) proteins are conserved tyrosine kinase receptors that play roles in a variety of cellular processes that pattern tissues and organs during vertebrate and invertebrate development. Ror signaling is required for skeleton and neuronal development and modulates cell migration, cell polarity, and convergent extension. Ror has also been implicated in two human skeletal disorders, brachydactyly type B and Robinow syndrome. Rors are widely expressed during metazoan development including domains in the nervous system. Here, we review recent progress in understanding the roles of the Ror receptors in neuronal migration, axonal pruning, axon guidance, and synaptic plasticity. The processes by which Ror signaling execute these diverse roles are still largely unknown, but they likely converge on cytoskeletal remodeling. In multiple species, Rors have been shown to act as Wnt receptors signaling via novel non-canonical Wnt pathways mediated in some tissues by the adapter protein disheveled and the non-receptor tyrosine kinase Src. Rors can either activate or repress Wnt target expression depending on the cellular context and can also modulate signal transduction by sequestering Wnt ligands away from their signaling receptors. Future challenges include the identification of signaling components of the Ror pathways and bettering our understanding of the roles of these pleiotropic receptors in patterning the nervous system.
Starting Page	303
Ending Page	315
Page Count	13
File Format	PDF
ISSN	08937648
Journal	Molecular Neurobiology
Volume Number	49
Issue Number	1
e-ISSN	15591182
Language	English
Publisher	Springer US
Publisher Date	2013-08-30
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ror Wnt CNS Neuronal Migration Axonal Branching and Pruning Synapse Neurosciences Neurobiology Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Neurology Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Role of Wnt Signaling in Central Nervous System Injury

Wnt Signaling in Skeletal Muscle Dynamics: Myogenesis, Neuromuscular Synapse and Fibrosis

MicroRNAs in Neuronal Communication

Current Understanding of Platelet-Activating Factor Signaling in Central Nervous System Diseases

Modulation of the NMDA Receptor Through Secreted Soluble Factors

Aspirin Promotes Oligodendroglial Differentiation Through Inhibition of Wnt Signaling Pathway

A Perspective on Neuronal Cell Death Signaling and Neurodegeneration

Matrix Metalloproteinases During Axonal Regeneration, a Multifactorial Role from Start to Finish

Inhibition of Retinal Ganglion Cell Axonal Outgrowth Through the Amino-Nogo-A Signaling Pathway

Wnt Signaling through the Ror Receptor in the Nervous System

Similar Documents

Role of Wnt Signaling in Central Nervous System Injury

Wnt Signaling in Skeletal Muscle Dynamics: Myogenesis, Neuromuscular Synapse and Fibrosis

MicroRNAs in Neuronal Communication

Current Understanding of Platelet-Activating Factor Signaling in Central Nervous System Diseases

Modulation of the NMDA Receptor Through Secreted Soluble Factors

Aspirin Promotes Oligodendroglial Differentiation Through Inhibition of Wnt Signaling Pathway

A Perspective on Neuronal Cell Death Signaling and Neurodegeneration

Matrix Metalloproteinases During Axonal Regeneration, a Multifactorial Role from Start to Finish

Inhibition of Retinal Ganglion Cell Axonal Outgrowth Through the Amino-Nogo-A Signaling Pathway

Wnt Signaling through the Ror Receptor in the Nervous System