NDLI: The Potential Roles of Aquaporin 4 in Alzheimer’s Disease

Content Provider	Springer Nature Link
Author	Lan, Yu Long Zhao, Jie Ma, Tonghui Li, Shao
Copyright Year	2015
Abstract	Aquaporin 4 (AQP4) is the major water channel expressed in the central nervous system (CNS), and it is primarily expressed in astrocytes. It has been studied in various brain pathological conditions. However, the potential for AQP4 to influence Alzheimer’s disease (AD) is still unclear. Research regarding AQP4 functions related to AD can be traced back several years and has gradually progressed toward a better understanding of the potential mechanisms. Currently, it has been suggested that AQP4 influences synaptic plasticity, and AQP4 deficiency may impair learning and memory, in part, through glutamate transporter-1 (GLT-1). AQP4 may mediate the clearance of amyloid beta peptides (Aβ). In addition, AQP4 may influence potassium (K$^{+}$) and calcium (Ca$^{2+}$) ion transport, which could play decisive roles in the pathogenesis of AD. Furthermore, AQP4 knockout is involved in neuroinflammation and interferes with AD. To date, no specific therapeutic agents have been developed to inhibit or enhance AQP4. However, experimental results strongly emphasize the importance of this topic for future investigations.
Starting Page	5300
Ending Page	5309
Page Count	10
File Format	PDF
ISSN	08937648
Journal	Molecular Neurobiology
Volume Number	53
Issue Number	8
e-ISSN	15591182
Language	English
Publisher	Springer US
Publisher Date	2015-10-03
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	AQP4 Alzheimer’s disease Synaptic plasticity GLT-1 Amyloid beta peptides Potassium (K$^{+}$) ion Calcium (Ca$^{2+}$) ion Neurosciences Neurobiology Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Neurology Cellular and Molecular Neuroscience

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