NDLI: A Population-based Association Study of Casein Kinase 1 Epsilon Loci with Heroin Dependence in Han Chinese

Content Provider	Springer Nature Link
Author	Wang, Yunpeng Zhu, Yongsheng Wang, Wei Wu, Feng Cui, Haimin Xun, Xi Lai, Jianghua
Copyright Year	2013
Abstract	Pharmacogenetic studies have confirmed that the genetic variant of the casein kinase 1 epsilon (Csnk1ε) gene contributes to response variability to amphetamine and methamphetamine in both mice and humans. A polymorphism in the Csnk1ε gene has been reported to be associated with heroin dependence. In this study, to identify markers contributing to the genetic susceptibility of the Csnk1ε gene to heroin dependence, we examined the potential association between heroin dependence and 14 single nucleotide polymorphisms (SNPs; rs1997644, rs135764, rs867198, rs135763, rs135757, rs6001090, rs5750581, rs1534891, rs1005473, rs3890379, rs2075984, rs2075983, rs135749, and rs135745) of the Csnk1ε gene using the MassARRAY system. Participants included 398 heroin-dependent patients and 436 healthy controls from a Han Chinese population. The result revealed a strong association between the rs135745 (3′-untranslated region) genotype distribution and heroin dependence (P = 0.0006). The frequency of the C allele was significantly higher in the heroin-dependent patients than in the healthy controls (χ$^{2}$ = 7.172, P = 0.007, OR = 1.426, 95 % CI = 1.099–1.849). Further genotype and clinical phenotype correlation study of the rs135745 carriers showed that the amount of heroin self-injection was higher in patients with the GC + CC genotype compared to the patients with the GG genotypes (P < 0.01). Strong linkage disequilibrium (LD) was observed in block 1, block 2, and block 3 (D′ > 0.9), whereas significant evidence of LD was not observed between these SNPs in our sample population. These findings point to a role for Csnk1ε polymorphisms in heroin dependence among the Han Chinese population and may be informative for future genetic or neurobiological studies on heroin dependence.
Starting Page	143
Ending Page	149
Page Count	7
File Format	PDF
ISSN	08958696
Journal	Journal of Molecular Neuroscience
Volume Number	53
Issue Number	2
e-ISSN	15591166
Language	English
Publisher	Springer US
Publisher Date	2013-12-17
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Heroin dependence Casein kinase 1 epsilon Single nucleotide polymorphisms Neurosciences Neurochemistry Cell Biology Proteomics Neurology
Content Type	Text
Resource Type	Article
Subject	Medicine Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Association Between a Casein Kinase 1 Epsilon Gene Polymorphism and Schizophrenia in a Chinese Han Population

The Evidence for the Contribution of the Autism Susceptibility Candidate 2 (AUTS2) Gene in Heroin Dependence Susceptibility

Association Between Neurotensin Receptor 1 Gene Polymorphisms and Alcohol Dependence in a Male Han Chinese Population

An Association Study Between Genetic Polymorphisms in Functional Regions of Five Genes and the Risk of Schizophrenia

Association of Single-Nucleotide Polymorphisms in the Cannabinoid Receptor 2 Gene with Schizophrenia in the Han Chinese Population

Association of Apolipoprotein M Gene Polymorphisms with Ischemic Stroke in a Han Chinese Population

Single Nucleotide Polymorphisms in SLC19A1 and SLC25A9 Are Associated with Childhood Autism Spectrum Disorder in the Chinese Han Population

No Association of a Casein Kinase 1ε (CK1ε) Gene Polymorphism with Personality Traits in Healthy Chinese-Han Subjects

Association Between Neurotensin Receptor 1 (NTR1) Gene Polymorphisms and Schizophrenia in a Han Chinese Population

A Population-based Association Study of Casein Kinase 1 Epsilon Loci with Heroin Dependence in Han Chinese

Similar Documents

Association Between a Casein Kinase 1 Epsilon Gene Polymorphism and Schizophrenia in a Chinese Han Population

The Evidence for the Contribution of the Autism Susceptibility Candidate 2 (AUTS2) Gene in Heroin Dependence Susceptibility

Association Between Neurotensin Receptor 1 Gene Polymorphisms and Alcohol Dependence in a Male Han Chinese Population

An Association Study Between Genetic Polymorphisms in Functional Regions of Five Genes and the Risk of Schizophrenia

Association of Single-Nucleotide Polymorphisms in the Cannabinoid Receptor 2 Gene with Schizophrenia in the Han Chinese Population

Association of Apolipoprotein M Gene Polymorphisms with Ischemic Stroke in a Han Chinese Population

Single Nucleotide Polymorphisms in SLC19A1 and SLC25A9 Are Associated with Childhood Autism Spectrum Disorder in the Chinese Han Population

No Association of a Casein Kinase 1ε (CK1ε) Gene Polymorphism with Personality Traits in Healthy Chinese-Han Subjects

Association Between Neurotensin Receptor 1 (NTR1) Gene Polymorphisms and Schizophrenia in a Han Chinese Population

A Population-based Association Study of Casein Kinase 1 Epsilon Loci with Heroin Dependence in Han Chinese