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| Content Provider | Springer Nature Link |
|---|---|
| Author | Flik, Gunnar Folgering, Joost H. A. Cremers, Thomas I. H. F. Westerink, Ben H. C. Dremencov, Eliyahu |
| Copyright Year | 2015 |
| Abstract | Brain monoamines (serotonin, norepinephrine, dopamine, and histamine) play an important role in emotions, cognition, and pathophysiology and treatment of mental disorders. The interactions between serotonin, norepinephrine, and dopamine were studied in numerous works; however, histamine system received less attention. The aim of this study was to investigate the interactions between histamine and other monoamines, using in vivo microdialysis and electrophysiology. It was found that the inverse agonist of histamine-3 receptors, thioperamide, increased the firing activity of dopamine neurons in the ventral tegmental area. Selective agonist of histamine-3 receptors, immepip, reversed thiperamide-induced stimulation of firing activity of dopamine neurons. The firing rates of serotonin and norpeinephrine neurons were not attenuated by immepip or thioperamide. Thioperamide robustly and significantly increased extracellular concentrations of serotonin, norepinephrine, and dopamine in the rat prefrontal cortex and slightly increased norepinephrine and dopamine levels in the tuberomammillary nucleus of the hypothalamus. It can be concluded that histamine stimulates serotonin, norepinephrine, and dopamine transmission in the brain. Modulation of firing of dopamine neurons is a key element in functional interactions between histamine and other monoamines. Antagonists of histamine-3 receptors, because of their potential ability to stimulate monoamine neurotransmission, might be beneficial in the treatment of mental disorders. |
| Starting Page | 320 |
| Ending Page | 328 |
| Page Count | 9 |
| File Format | |
| ISSN | 08958696 |
| Journal | Journal of Molecular Neuroscience |
| Volume Number | 56 |
| Issue Number | 2 |
| e-ISSN | 15591166 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2015-03-29 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Histamine-3 (H$_{3}$) receptors Thioperamide Immepip Tuberomammillary nucleus (TMN) of hypothalamus Dorsal raphe nucleus (DRN) Locus coeruleus (LC) Ventral tegmental area (VTA) Prefrontal cortex (PFC) Neurosciences Neurochemistry Cell Biology Proteomics Neurology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cellular and Molecular Neuroscience |
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