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| Content Provider | Springer Nature Link |
|---|---|
| Author | Fan, Shaochen Zhao, Chengjin Zhang, Li Dai, Shirong Ren, Jianbing Zhang, Xiubing Ban, Na He, Xiaojuan Yang, Lixiang Bao, Zhen Chen, Wenjuan Sun, Jie Gao, Yilu Tao, Tao |
| Copyright Year | 2015 |
| Abstract | The prognosis of glioma patients is generally poor, so it is urgent to find out the underlying molecular mechanisms. PFTK1 is a member of cyclin-dependent kinases (Cdks) family and has been reported to contribute to tumor migration and invasion. In this study, we aimed to explore the expression and function in human glioma. Western blot and immunohistochemistry were used to evaluate the expression of PFTK1. PFTK1 expression was higher in glioma tissues compared with normal brain tissues, and its level was associated with the WHO grade in Western blot analysis. The suppression of PFTK1 expression by RNA interference was shown to inhibit the migration of glioma cells. Knockdown of PFTK1 increases E-cadherin expression and decreases vimentin expression. These data show that PFTK1 may participate in the pathogenic process of glioma, suggesting that PFTK1 can become a potential therapeutic strategy for gastric cancer. |
| Starting Page | 257 |
| Ending Page | 264 |
| Page Count | 8 |
| File Format | |
| ISSN | 08958696 |
| Journal | Journal of Molecular Neuroscience |
| Volume Number | 57 |
| Issue Number | 2 |
| e-ISSN | 15591166 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2015-08-04 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Glioma PFTK1 Migration Knockdown E-cadherin Neurosciences Neurochemistry Cell Biology Proteomics Neurology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cellular and Molecular Neuroscience |
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