NDLI: The Multiple Phenotypes of Corticobasal Syndrome and Corticobasal Degeneration: Implications for Further Study

Content Provider	Springer Nature Link
Author	Boeve, Bradley F.
Copyright Year	2011
Abstract	Corticobasal degeneration (CBD) is a complex neurodegenerative disorder which nomenclature of which its nomenclature and characterization continues to evolve. The core clinical features that have been considered characteristic of the disorder include progressive asymmetric rigidity and apraxia, with other findings suggesting additional cortical (e.g., alien limb phenomena, cortical sensory loss, myoclonus, and mirror movements) and basal ganglionic (e.g., bradykinesia, dystonia, and tremor) dysfunctions. The characteristic findings at autopsy are asymmetric cortical atrophy that is typically maximal in the frontoparietal regions, as well as basal ganglia and nigral degeneration. Microscopically, abnormal accumulations of the microtubule-associated tau protein are found in both neurons and glia, and this disorder is now considered one of the “tauopathies.” CBD was initially thought to represent a distinct clinicopathologic entity. Recent studies have shown considerable clinicopathologic heterogeneity, leading some to use the term “corticobasal syndrome” (CBS) for the constellation of findings initially considered characteristic of the disorder, and the term “corticobasal degeneration” for the histopathologic disorder. In this review, the multiple phenotypes/syndromes associated with CBD pathology, and multiple diseases associated with the CBS, are presented. The clinicopathologic heterogeneity in CBS/CBD and the implications of this heterogeneity on clinical practice, on understanding the focal/asymmetric cerebral degeneration syndromes, and on future research are all reviewed.
Starting Page	350
Ending Page	353
Page Count	4
File Format	PDF
ISSN	08958696
Journal	Journal of Molecular Neuroscience
Volume Number	45
Issue Number	3
e-ISSN	15591166
Language	English
Publisher	Humana Press Inc
Publisher Date	2011-08-19
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Corticobasal degeneration Corticobasal syndrome Apraxia Alien limb phenomenon Tau Neurology Neurosciences Cell Biology Proteomics Neurochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)

Parkinsonism and Frontotemporal Dementia: The Clinical Overlap

Symmetrical Corticobasal Syndrome Caused by a Novel c.314dup Progranulin Mutation

Extrapyramidal Syndromes in Frontotemporal Degeneration

Behavioral Variant Frontotemporal Dementia with Corticobasal Degeneration Pathology: Phenotypic Comparison to bvFTD with Pick’s Disease

Alien limb in the corticobasal syndrome: phenomenological characteristics and relationship to apraxia.

The Frontotemporal Syndromes of ALS. Clinicopathological Correlates

Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders

Microtubule-Tau Interaction as a Therapeutic Target for Alzheimer’s Disease

The Multiple Phenotypes of Corticobasal Syndrome and Corticobasal Degeneration: Implications for Further Study

Similar Documents

Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)

Parkinsonism and Frontotemporal Dementia: The Clinical Overlap

Symmetrical Corticobasal Syndrome Caused by a Novel c.314dup Progranulin Mutation

Extrapyramidal Syndromes in Frontotemporal Degeneration

Behavioral Variant Frontotemporal Dementia with Corticobasal Degeneration Pathology: Phenotypic Comparison to bvFTD with Pick’s Disease

Alien limb in the corticobasal syndrome: phenomenological characteristics and relationship to apraxia.

The Frontotemporal Syndromes of ALS. Clinicopathological Correlates

Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders

Microtubule-Tau Interaction as a Therapeutic Target for Alzheimer’s Disease

The Multiple Phenotypes of Corticobasal Syndrome and Corticobasal Degeneration: Implications for Further Study