NDLI: Apolipoprotein ε4-Allele as a Significant Risk Factor for Conversion from Mild Cognitive Impairment to Alzheimer’s disease: a Meta-analysis of Prospective Studies

Content Provider	Springer Nature Link
Author	Fei, Ma Jianhua, Wang
Copyright Year	2012
Abstract	Recent studies of the relationship between progression from mild cognitive impairment (MCI) to Alzheimer disease (AD) and APOE ε4-allele revealed inconsistent results. To estimate the risk posed by APOE ε4-allele for developing AD in MCI subjects using meta-analysis and identify possible sources of heterogeneity between studies, we reviewed longitudinal epidemiological studies of the presence of APOE ε4-allele on risk for progression to dementia in MCI subjects, and conducted meta-analyses of the results from these studies. Our study was derived from 315 positive-outcome events and 461 negative-outcome events from 8 prospective studies. The pooled RR was statistically significant (pooled RR = 2.09; 95 % CI, 1.52–2.88). The Q statistics indicated high heterogeneity across studies (Q = 14.21, p = 0.003). RR were significantly related to the ethnicity of the sample (z = 3.58, p = 0.024). No significant heterogeneity was observed after stratification in four European-population studies (χ $^{2}$ = 0.67, p = 0.880), but it remained in four American-population studies (χ $^{2}$ = 18.52, p = 0.003). Heterogeneity markedly reduced after excluding one specific study (Q = 4.9, p = 0.009; I $^{2}$ = 39 %). APOE ε4-allele conferred increased risk for progression to dementia in MCI subjects. Ethnicity is a critical factor to yield heterogeneity. Further studies using larger sample sizes are required.
Starting Page	257
Ending Page	263
Page Count	7
File Format	PDF
ISSN	08958696
Journal	Journal of Molecular Neuroscience
Volume Number	50
Issue Number	2
e-ISSN	15591166
Language	English
Publisher	Humana Press Inc
Publisher Date	2012-12-15
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mild cognitive impairment Alzheimer disease Meta-analysis Heterogeneity Neurosciences Neurochemistry Cell Biology Proteomics Neurology
Content Type	Text
Resource Type	Article
Subject	Medicine Cellular and Molecular Neuroscience

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