NDLI: Altered microRNA Expression in Peripheral Blood Mononuclear Cells from Young Patients with Schizophrenia

Content Provider	Springer Nature Link
Author	Fan, Hui min Sun, Xin yang Niu, Wei Zhao, Lin Zhang, Qiao Li Li, Wan shuai Zhong, Ai fang Zhang, Li yi Lu, Jim
Copyright Year	2015
Abstract	Schizophrenia (SZ) is a debilitating psychotic disorder of unknown etiology, and the diagnosis is essentially based on clinical symptoms. So it is urgent to find an objective and feasible clinical diagnostic index for SZ. MicroRNA array was performed in peripheral blood mononuclear cells (PBMCs) obtained from young SZ patients and gender-, age-, and ethnicity-matched healthy controls. Then, real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to verify the top 10 microRNAs (miRNAs) with the highest fold change values in 55 SZ patients and 28 healthy controls, and 9 miRNAs demonstrate significant differences in expression levels (P < 0.01). Receiver operating characteristic (ROC) curve analysis showed that the combining area under the ROC curve (AUC) of the nine miRNAs was 0.973 (95 % confidence interval (CI): 0.945–1.000). miRNA target gene prediction and functional annotation analysis showed that there were significant enrichments in several gene ontology (GO) biological process and Kyoto encyclopedia of genes and genomes (KEGG) pathways associated with nervous system and brain functions, suggesting that the differentially expressed miRNAs may be involved in mechanism of SZ. We conclude that altered expression of miRNAs in PMBCs might be involved in young SZ pathogenesis and may serve as noninvasive biomarker for SZ diagnosis.
Starting Page	562
Ending Page	571
Page Count	10
File Format	PDF
ISSN	08958696
Journal	Journal of Molecular Neuroscience
Volume Number	56
Issue Number	3
e-ISSN	15591166
Language	English
Publisher	Springer US
Publisher Date	2015-02-11
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Schizophrenia microRNA Peripheral blood mononuclear cells microRNA array Target gene prediction Functional annotation analysis Neurosciences Neurochemistry Cell Biology Proteomics Neurology
Content Type	Text
Resource Type	Article
Subject	Medicine Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

MicroRNA Expression Aberration in Chinese Patients with Relapsing Remitting Multiple Sclerosis

Altered Expression of Specific Transcription Factors of Th17 (RORγt, RORα) and Treg Lymphocytes (FOXP3) by Peripheral Blood Mononuclear Cells from Patients with Multiple Sclerosis

In Vivo MicroRNA Detection and Quantitation in Cerebrospinal Fluid

Early Thyroid Hormone-induced Gene Expression Changes in N2a-β Neuroblastoma Cells

Evaluation of Six SNPs of MicroRNA Machinery Genes and Risk of Schizophrenia

Identification and Potential Regulatory Properties of Evolutionary Conserved Regions (ECRs) at the Schizophrenia-Associated MIR137 Locus

Erratum to: Altered NR4A Subfamily Gene Expression Level in Peripheral Blood of Parkinson’s and Alzheimer’s Disease Patients

Novel Gene Expression Model for Outcome Prediction in Paediatric Medulloblastoma

Plasma and White Blood Cells Show Different miRNA Expression Profiles in Parkinson’s Disease

Altered microRNA Expression in Peripheral Blood Mononuclear Cells from Young Patients with Schizophrenia

Similar Documents

MicroRNA Expression Aberration in Chinese Patients with Relapsing Remitting Multiple Sclerosis

Altered Expression of Specific Transcription Factors of Th17 (RORγt, RORα) and Treg Lymphocytes (FOXP3) by Peripheral Blood Mononuclear Cells from Patients with Multiple Sclerosis

In Vivo MicroRNA Detection and Quantitation in Cerebrospinal Fluid

Early Thyroid Hormone-induced Gene Expression Changes in N2a-β Neuroblastoma Cells

Evaluation of Six SNPs of MicroRNA Machinery Genes and Risk of Schizophrenia

Identification and Potential Regulatory Properties of Evolutionary Conserved Regions (ECRs) at the Schizophrenia-Associated MIR137 Locus

Erratum to: Altered NR4A Subfamily Gene Expression Level in Peripheral Blood of Parkinson’s and Alzheimer’s Disease Patients

Novel Gene Expression Model for Outcome Prediction in Paediatric Medulloblastoma

Plasma and White Blood Cells Show Different miRNA Expression Profiles in Parkinson’s Disease

Altered microRNA Expression in Peripheral Blood Mononuclear Cells from Young Patients with Schizophrenia