NDLI: Evaluation of the MTHFR A1298C Variant in Leukoaraiosis

Content Provider	Springer Nature Link
Author	Szolki, Zoltan Szaniszlo, Istvan Szekeres, Marta Hitri, Krisztina Kondacs, Andras Mandi, Yvette Nedo, Erika Somogyvari, Ferenc
Copyright Year	2011
Abstract	Vascular demyelinization of the white matter of the brain is referred to as leukoaraiosis (LA). This very frequent entity is associated with a cognitive decline, thereby resulting in a deteriorating quality of life. Besides poorly controlled hypertension and aging, its development is reported to be associated with an elevated serum homocysteine level. Although the methylenetetrahydrofolate reductase (MTHFR) C677T genetic variant is associated with an elevated serum homocysteine level, it has not been proved to be an independent risk factor for LA. The aim of the present study was to examine whether the MTHFR A1298C genetic variant, which is also believed to be unfavorable, is associated with the presence of LA. The clinical and genetic data on 198 LA patients and 235 neuroimaging alteration-free controls were analyzed. The presence of the A1298C or the 1298CC variant was calculated to be a risk factor for LA, as compared with the absence of both of them. The clustering of the heterozygous A1298C and C677T variants was proved to involve the risk of LA. Our results suggest that the MTHFR A1298C variant confers an independent genetic risk of LA, and this pathological role may be amplified by the MTHFR C677T variant.
Starting Page	492
Ending Page	496
Page Count	5
File Format	PDF
ISSN	08958696
Journal	Journal of Molecular Neuroscience
Volume Number	46
Issue Number	3
e-ISSN	15591166
Language	English
Publisher	Humana Press Inc
Publisher Date	2011-08-16
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Leukoaraiosis Genetics Risk factors Genetic variants MTHFR Neurology Cell Biology Neurochemistry Proteomics Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cyclooxygenase 2 Genetic Polymorphism May Increase the Risk of Developing Leukoaraiosis in Chinese

Erratum to: Genetic Screening of Pediatric Cavernous Malformations

Genetic Counseling for Frontotemporal Dementias

Poster Abstracts

Mutational Screening of PARKIN Identified a 3′ UTR Variant (rs62637702) Associated with Parkinson’s Disease

Eating Disturbance in Behavioural-Variant Frontotemporal Dementia

Neuropeptides 2013 Conference

Erratum to: Poster Abstracts

Variants of COL3A1 Are Associated with the Risk of Stroke Recurrence and Prognosis in the Chinese Population: a Prospective Study

Evaluation of the MTHFR A1298C Variant in Leukoaraiosis

Similar Documents

Cyclooxygenase 2 Genetic Polymorphism May Increase the Risk of Developing Leukoaraiosis in Chinese

Erratum to: Genetic Screening of Pediatric Cavernous Malformations

Genetic Counseling for Frontotemporal Dementias

Poster Abstracts

Mutational Screening of PARKIN Identified a 3′ UTR Variant (rs62637702) Associated with Parkinson’s Disease

Eating Disturbance in Behavioural-Variant Frontotemporal Dementia

Neuropeptides 2013 Conference

Erratum to: Poster Abstracts

Variants of COL3A1 Are Associated with the Risk of Stroke Recurrence and Prognosis in the Chinese Population: a Prospective Study

Evaluation of the MTHFR A1298C Variant in Leukoaraiosis