NDLI: Coenzyme Q$_{10}$ provides neuroprotection in iron-induced apoptosis in dopaminergic neurons

Content Provider	Springer Nature Link
Author	Kooncumchoo, Patcharee Sharma, Sushil Porter, James Govitrapong, Piyarat Ebadi, Manuchir
Copyright Year	2006
Abstract	The exact molecular mechanism of progressive loss of neuromelanin containing nigrostriatal dopaminergic neurons in Parkinson's disease (PD) remains unknown, yet evidence suggests that iron might play an important role in PD pathology. In this study we have determined the neuroprotective role of coenzyme Q$_{10}$ (CoQ$_{10}$) in iron-induced apoptosis in cultured human dopaminergic (SK-N-SH) neurons, in metallothionein gene-manipulated mice, and in α-synuclein knockout (α-synko) mice with a primary objective to assess a possible therapeutic and anti-inflammatory potential for CoQ$_{10}$ in PD. Iron-induced mitochondrial damage and apoptosis were characterized by reactive oxygen species production, increased metallothionein and glutathione synthesis, caspase-3 activation, NF-κB induction, and decreased Bcl-2 expression, without any significant change in Bax expression. Lower concentrations of FeSO$_{4}$ (1–10 μM) induced perinuclear aggregation of mitochondria, whereas higher concentrations (100–250 μM) induced CoQ$_{10}$ depletion, plasma membrane perforations, mitochondrial damage, and nuclear DNA condensation and fragmentation. FeSO$_{4}$-induced deleterious changes were attenuated by pretreatment with CoQ$_{10}$ and by deferoxamine, a potent iron chelator, in SK-N-SH cells. 1-Methyl, 4-phenyl, 1,2,3,6-tetrahydropyridine (MPTP)-induced striatal release of free iron, and NF-κB expression were significantly increased; whereas ferritin and melanin synthesis were significnatly reduced in the substantia nigra pars compacta (SN pc) of MT$_{dko}$ mice as compared with control$_{wt}$ mice, MT$_{trans}$ mice, and α-synko mice. CoQ$_{10}$ treatment inhibited MPTP-induced NF-κB induction in all of the genotypes. These data suggest that glutathione and metallothionein synthesis might be induced as an attempt to combat iron-induced oxidative stress, whereas exogenous administration of CoQ$_{10}$ or of metallothionein induction might provide CoQ$_{10}$-mediated neuroprotection in PD.
Starting Page	125
Ending Page	141
Page Count	17
File Format	PDF
ISSN	08958696
Journal	Journal of Molecular Neuroscience
Volume Number	28
Issue Number	2
e-ISSN	15591166
Language	English
Publisher	Humana Press
Publisher Date	2006-01-01
Publisher Place	Totowa
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurosciences Neurology
Content Type	Text
Resource Type	Article
Subject	Medicine Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

IL6 Protects MN9D Cells and Midbrain Dopaminergic Neurons from MPP$^{+}$-Induced Neurodegeneration

Food, Nutrigenomics, and Neurodegeneration—Neuroprotection by What You Eat!

Human Coenzyme Q$_{10}$ Deficiency

Increased Calpain Expression Is Associated with Apoptosis in Rat Spinal Cord Injury: Calpain Inhibitor Provides Neuroprotection

Curcumin Protects Dopaminergic Neuron Against LPS Induced Neurotoxicity in Primary Rat Neuron/Glia Culture

Effects of DDIT4 in Methamphetamine-Induced Autophagy and Apoptosis in Dopaminergic Neurons

C5a Receptor (CD88) Inhibition Improves Hypothermia-Induced Neuroprotection in an In Vitro Ischemic Model

Dopamine Selectively Sensitizes Dopaminergic Neurons to Rotenone-Induced Apoptosis

Distribution of Coenzyme Q Homologues in Brain

Coenzyme Q$_{10}$ provides neuroprotection in iron-induced apoptosis in dopaminergic neurons

Similar Documents

IL6 Protects MN9D Cells and Midbrain Dopaminergic Neurons from MPP$^{+}$-Induced Neurodegeneration

Food, Nutrigenomics, and Neurodegeneration—Neuroprotection by What You Eat!

Human Coenzyme Q$_{10}$ Deficiency

Increased Calpain Expression Is Associated with Apoptosis in Rat Spinal Cord Injury: Calpain Inhibitor Provides Neuroprotection

Curcumin Protects Dopaminergic Neuron Against LPS Induced Neurotoxicity in Primary Rat Neuron/Glia Culture

Effects of DDIT4 in Methamphetamine-Induced Autophagy and Apoptosis in Dopaminergic Neurons

C5a Receptor (CD88) Inhibition Improves Hypothermia-Induced Neuroprotection in an In Vitro Ischemic Model

Dopamine Selectively Sensitizes Dopaminergic Neurons to Rotenone-Induced Apoptosis

Distribution of Coenzyme Q Homologues in Brain

Coenzyme Q$_{10}$ provides neuroprotection in iron-induced apoptosis in dopaminergic neurons