NDLI: Building a FP-CIT SPECT Brain Template Using a Posterization Approach

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Building a FP-CIT SPECT Brain Template Using a Posterization Approach

Content Provider	Springer Nature Link
Author	Salas Gonzalez, D. Górriz, Juan M. Ramírez, Javier Illán, Ignacio A. Padilla, Pablo Martínez Murcia, Francisco J. Lang, Elmar W.
Copyright Year	2015
Abstract	Spatial affine registration of brain images to a common template is usually performed as a preprocessing step in intersubject and intrasubject comparison studies, computer-aided diagnosis, region of interest selection and brain segmentation in tomography. Nevertheless, it is not straightforward to build a template of [123I]FP-CIT SPECT brain images because they exhibit very low intensity values outside the striatum. In this work, we present a procedure to automatically build a [123I]FP-CIT SPECT template in the standard Montreal Neurological Institute (MNI) space. The proposed methodology consists of a head voxel selection using the Otsu’s method, followed by a posterization of the source images to three different levels: background, head, and striatum. Analogously, we also design a posterized version of a brain image in the MNI space; subsequently, we perform a spatial affine registration of the posterized source images to this image. The intensity of the transformed images is normalized linearly, assuming that the histogram of the intensity values follows an alpha-stable distribution. Lastly, we build the [123I]FP-CIT SPECT template by means of the transformed and normalized images. The proposed methodology is a fully automatic procedure that has been shown to work accurately even when a high-resolution magnetic resonance image for each subject is not available.
Starting Page	391
Ending Page	402
Page Count	12
File Format	PDF
ISSN	15392791
Journal	Neuroinformatics
Volume Number	13
Issue Number	4
e-ISSN	15590089
Language	English
Publisher	Springer US
Publisher Date	2015-03-07
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	FP-CIT SPECT brain images Spatial normalization Template Parkinson Neurosciences Bioinformatics Computational Biology/Bioinformatics Computer Application in Life Sciences Neurology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Information Systems Software

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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