NDLI: Structure-Based Neuron Retrieval Across Drosophila Brains

Content Provider	Springer Nature Link
Author	Ganglberger, Florian Schulze, Florian Tirian, Laszlo vikov, Alexey Dickson, Barry Bühler, Katja Langs, Georg
Copyright Year	2014
Abstract	Comparing local neural structures across large sets of examples is crucial when studying gene functions, and their effect in the Drosophila brain. The current practice of aligning brain volume data to a joint reference frame is based on the neuropil. However, even after alignment neurons exhibit residual location and shape variability that, together with image noise, hamper direct quantitative comparison and retrieval of similar structures on an intensity basis. In this paper, we propose and evaluate an image-based retrieval method for neurons, relying on local appearance, which can cope with spatial variability across the population. For an object of interest marked in a query case, the method ranks cases drawn from a large data set based on local neuron appearance in confocal microscopy data. The approach is based on capturing the orientation of neurons based on structure tensors and expanding this field via Gradient Vector Flow. During retrieval, the algorithm compares fields across cases, and calculates a corresponding ranking of most similar cases with regard to the local structure of interest. Experimental results demonstrate that the similarity measure and ranking mechanisms yield high precision and recall in realistic search scenarios.
Starting Page	423
Ending Page	434
Page Count	12
File Format	PDF
ISSN	15392791
Journal	Neuroinformatics
Volume Number	12
Issue Number	3
e-ISSN	15590089
Language	English
Publisher	Springer US
Publisher Date	2014-01-21
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Drosophila Neuron retrieval Structure tensor Similarity measure Gradient vector flow Neurosciences Bioinformatics Computational Biology/Bioinformatics Computer Application in Life Sciences Neurology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Information Systems Software

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