NDLI: Lack of Association Between MAGEL2 and Schizophrenia and Mood Disorders in the Japanese Population

Content Provider	Springer Nature Link
Author	Fukuo, Yasuhisa Kishi, Taro Okochi, Tomo Kitajima, Tsuyoshi Tsuka, Tomoko Okumukura, Takeri Kishita, Yoko Kawashima, Kunihiro Yamauchi, Yoshio Umene Naka, Wakako Naitoh, Hiroshi Inada, Toshiya Yoshimura, Reiji Nakamura, Jun Ozaki, rio Iwata, Nakao
Copyright Year	2010
Abstract	Several investigations have reported that abnormalities in circadian rhythms might be related with the pathophysiology of psychiatric disorders, since many psychiatric patients have insomnia and sleep-awake disturbance. A recent animal study reported that Magel2, which encodes a member of the MAGE/necdin family of proteins, might be associated in the pathophysiology of psychiatric disorders. Magel2 gene knockout mice showed altered concentrations of both dopamine and serotonin in several parts of the brain compared with controls. In addition, the authors of that study detected a bilateral reduction in cortical volume in distinct regions of the Magel2 gene knockout mice brain, including focused regions in the parieto-temporal lobe of the cerebral cortex, the amygdala, the hippocampus, and the nucleus accumbens. These mice were also found to have hypoactivity and abnormalities in circadian rhythms. From this evidence, we considered Magel2 gene (MAGEL2) to be a good candidate gene for the pathophysiology of schizophrenia and mood disorder, and we conducted a case–control study among Japanese (731 schizophrenia patients, 465 MDD patients, 156 BP patients and 758 controls) using three tagging SNPs in MAGEL2 (rs850815, rs8920 and rs4480754), selected using the HapMap database. We did not find any association between MAGEL2 and schizophrenia, BP or MDD in allele/genotype-wise analysis or haplotype-wise analysis. Our results suggest that MAGEL2 may not play a role in the pathophysiology of schizophrenia and mood disorders in the Japanese population. A replication study using larger samples may be required for conclusive results, since our sample size was small and our study analyzed only three SNPs in MAGEL2.
Starting Page	285
Ending Page	291
Page Count	7
File Format	PDF
ISSN	15351084
Journal	NeuroMolecular Medicine
Volume Number	12
Issue Number	3
e-ISSN	15591174
Language	English
Publisher	Humana Press Inc
Publisher Date	2010-05-14
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Major depressive disorder Bipolar disorder Schizophrenia MAGEL2 Linkage disequilibrium Tagging SNP Internal Medicine Neurology Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Neurology Molecular Medicine Cellular and Molecular Neuroscience

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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