NDLI: Association of TOMM40 Polymorphisms with Late-Onset Alzheimer’s Disease in a Northern Han Chinese Population

Content Provider	Springer Nature Link
Author	Ma, Xiao Ying Yu, Jin Tai Wang, Wei Wang, Hui Fu Liu, Qiu Yan Zhang, Wei Tan, Lan
Copyright Year	2013
Abstract	Mitochondrial dysfunction is an early defect in the pathogenesis of late-onset Alzheimer’s disease (LOAD). One interesting candidate gene for mitochondrial dysfunction in LOAD is the translocase of outer mitochondrial membrane 40 homolog (TOMM40) gene. Several single nucleotide polymorphisms (SNPs) within TOMM40 have been shown to affect susceptibility to LOAD in Caucasians, while there are no studies on the association of the polymorphisms with LOAD risk in Han Chinese. Here, the association of TOMM40 polymorphisms in LOAD was investigated in a large Northern Han Chinese cohort consisting of 1,578 individuals. Both allelic and genotypic associations of three SNPs (rs157580, rs2075650, and rs11556505) with LOAD risk were observed in the total sample as well as in the non- APOE ε4 carriers. For rs1160985, the allele and genotype frequencies differed significantly only in APOE ε4 carriers. After adjustment for age, gender, and APOE ε4 status, the association remained statistically significant only for the rs157580 but not for rs2075650 and rs11556505. In contrast, the rs1160985 exhibited significant risk effect after adjustment. In addition, haplotype analysis confirmed that the haplotypes derived from SNPs in rs2075650, rs11556505, and rs1160985 were associated with either risk or protective effects. In summary, our findings suggest that the TOMM40 polymorphisms may play a role in the pathogenesis of LOAD in Han Chinese.
Starting Page	279
Ending Page	287
Page Count	9
File Format	PDF
ISSN	15351084
Journal	NeuroMolecular Medicine
Volume Number	15
Issue Number	2
e-ISSN	15591174
Language	English
Publisher	Humana Press Inc
Publisher Date	2013-01-04
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	TOMM40 Alzheimer’s disease Polymorphism Association study Neurosciences Neurology Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Neurology Molecular Medicine Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Association of DISC1 Polymorphisms with Late-Onset Alzheimer’s Disease in Northern Han Chinese

Association of Single-Nucleotide Polymorphism in ANK1 with Late-Onset Alzheimer’s Disease in Han Chinese

Genetic association of BACE1 gene polymorphism C786G with late-onset Alzheimer’s disease in Chinese

Genetic Association of SLC2A14 Polymorphism with Alzheimer’s Disease in a Han Chinese Population

Genetic Factors Affecting Late-Onset Alzheimer’s Disease Susceptibility

Association of Parkinson’s Disease GWAS-Linked Loci with Alzheimer’s Disease in Han Chinese

Association Between Alzheimer’s Disease and the NOS3 gene Glu298Asp Polymorphism in Chinese

Association of MTHFR gene polymorphism C677T with susceptibility to late-onset alzheimer’s disease

Association of the p22phox polymorphism C242T with the risk of late-onset Alzheimer's disease in a northern Han Chinese population.

Association of TOMM40 Polymorphisms with Late-Onset Alzheimer’s Disease in a Northern Han Chinese Population

Similar Documents

Association of DISC1 Polymorphisms with Late-Onset Alzheimer’s Disease in Northern Han Chinese

Association of Single-Nucleotide Polymorphism in ANK1 with Late-Onset Alzheimer’s Disease in Han Chinese

Genetic association of BACE1 gene polymorphism C786G with late-onset Alzheimer’s disease in Chinese

Genetic Association of SLC2A14 Polymorphism with Alzheimer’s Disease in a Han Chinese Population

Genetic Factors Affecting Late-Onset Alzheimer’s Disease Susceptibility

Association of Parkinson’s Disease GWAS-Linked Loci with Alzheimer’s Disease in Han Chinese

Association Between Alzheimer’s Disease and the NOS3 gene Glu298Asp Polymorphism in Chinese

Association of MTHFR gene polymorphism C677T with susceptibility to late-onset alzheimer’s disease

Association of the p22phox polymorphism C242T with the risk of late-onset Alzheimer's disease in a northern Han Chinese population.

Association of TOMM40 Polymorphisms with Late-Onset Alzheimer’s Disease in a Northern Han Chinese Population