NDLI: The Aβ Peptides-Activated Calcium-Sensing Receptor Stimulates the Production and Secretion of Vascular Endothelial Growth Factor-A by Normoxic Adult Human Cortical Astrocytes

Please wait, while we are loading the content...

The Aβ Peptides-Activated Calcium-Sensing Receptor Stimulates the Production and Secretion of Vascular Endothelial Growth Factor-A by Normoxic Adult Human Cortical Astrocytes

Diabetes Mellitus and Disturbances in Brain Connectivity: A Bidirectional Relationship?

Dietary Lipid Unsaturation Influences Survival and Oxidative Modifications of an Amyotrophic Lateral Sclerosis Model in a Gender-Specific Manner

Apolipoprotein E Isoform-Specific Effects on Lipoprotein Receptor Processing

Aberrant DNA Methylation of Blood in Schizophrenia by Adjusting for Estimated Cellular Proportions

Phosphoinositide 3-Kinase γ Affects LPS-Induced Disturbance of Blood–Brain Barrier Via Lipid Kinase-Independent Control of cAMP in Microglial Cells

Mitochondrial Oxidative Phosphorylation Transcriptome Alterations in Human Amyotrophic Lateral Sclerosis Spinal Cord and Blood

Inhibitors of Histone Deacetylases Enhance Neurotoxicity of DNA Damage

No Association Between NRG1 and ErbB4 Genes and Psychopathological Symptoms of Schizophrenia

Direct Effect of Bevacizumab on Glioblastoma Cell Lines In Vitro

Propofol Protects Against Angiotensin II-Induced Mouse Hippocampal HT22 Cells Apoptosis Via Inhibition of p66$^{Shc}$ Mitochondrial Translocation

Oculopharyngeal Muscular Dystrophy: Phenotypic and Genotypic Studies in a Chinese Population

Multiple Mechanisms of Iron-Induced Amyloid Beta-Peptide Accumulation in SHSY5Y Cells: Protective Action of Negletein

Spinal Cord Injury and the Neuron-Intrinsic Regeneration-Associated Gene Program

A Quantitative Assessment of the Association Between 1425G/A Polymorphism in PRKCH and Risk of Stroke

A Diagnostic Approach for Cerebral Palsy in the Genomic Era

Epigenome-Wide Association Study for Parkinson’s Disease

A Polymorphism in the Promoter Region of the Survivin Gene is Related to Hemorrhagic Transformation in Patients with Acute Ischemic Stroke

Impairment of Brain Mitochondrial Charybdotoxin- and ATP-Insensitive BK Channel Activities in Diabetes

Lithium/Valproic Acid Combination and l-Glutamate Induce Similar Pattern of Changes in the Expression of miR-30a-5p in SH-SY5Y Neuroblastoma Cells

NeuroMolecular Medicine : Volume 16, Issue 3, September 2014

NeuroMolecular Medicine : Volume 16, Issue 2, June 2014

NeuroMolecular Medicine : Volume 16, Issue 1, March 2014

NeuroMolecular Medicine : Volume 15

NeuroMolecular Medicine : Volume 14

NeuroMolecular Medicine : Volume 13

NeuroMolecular Medicine : Volume 12

NeuroMolecular Medicine : Volume 11

NeuroMolecular Medicine : Volume 10

NeuroMolecular Medicine : Volume 9

NeuroMolecular Medicine : Volume 8

NeuroMolecular Medicine : Volume 7

NeuroMolecular Medicine : Volume 6

NeuroMolecular Medicine : Volume 5

NeuroMolecular Medicine : Volume 4

NeuroMolecular Medicine : Volume 3

NeuroMolecular Medicine : Volume 2

NeuroMolecular Medicine : Volume 1

The Aβ Peptides-Activated Calcium-Sensing Receptor Stimulates the Production and Secretion of Vascular Endothelial Growth Factor-A by Normoxic Adult Human Cortical Astrocytes

Content Provider	Springer Nature Link
Author	Dal Prà, Ilaria Armato, Ubaldo Chioffi, Franco Pacchiana, Raffaella Whitfield, James F. Chakravarthy, Balu Gui, Li Chiarini, Anna
Copyright Year	2014
Abstract	The excess vascular endothelial growth factor (VEGF) produced in the Alzheimer’s disease (AD) brain can harm neurons, blood vessels, and other components of the neurovascular units (NVUs). But could astrocytes partaking in networks of astrocyte-neuron teams and connected to blood vessels of NVUs contribute to VEGF production? We have shown with cultured cerebral cortical normal (i.e., untransformed) adult human astrocytes (NAHAs) that exogenous amyloid-β peptides (Aβs) stimulate the astrocytes to make and secrete large amounts of Aβs and nitric oxide by a mechanism mediated through the calcium-sensing receptor (CaSR). Here, we report that exogenous Aβs stimulate the NAHAs to produce and secrete even VEGF-A through a CaSR-mediated mechanism. This is indicated by the ability of Aβs to specifically bind the CaSR, and the capability of a CaSR activator, the “calcimimetic” NPS R-568, to imitate, and of the CaSR antagonist, “calcilytic” NPS 2143, to inhibit, the Aβs stimulation of VEGF-A production and secretion by the NAHAs. Thus, Aβs that accumulate in the AD brain may make the astrocytes that envelop and functionally collaborate with neurons into multi-agent AD-driving “machines” via a CaSR signaling mechanism(s). These observations suggest the possibility that CaSR allosteric antagonists such as NPS 2143 might impede AD progression.
Starting Page	645
Ending Page	657
Page Count	13
File Format	PDF
ISSN	15351084
Journal	NeuroMolecular Medicine
Volume Number	16
Issue Number	4
e-ISSN	15591174
Language	English
Publisher	Springer US
Publisher Date	2014-06-20
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Amyloid-β Human adult Astrocyte Calcimimetic Calcilytic Calcium-sensing receptor Vascular endothelial growth factor-A Neurosciences Neurology Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Neurology Molecular Medicine Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer's Disease

Amyloid β-Exposed Human Astrocytes Overproduce Phospho-Tau and Overrelease It within Exosomes, Effects Suppressed by Calcilytic NPS 2143—Further Implications for Alzheimer's Therapy

Amyloid β-Peptide Directly Induces Spontaneous Calcium Transients, Delayed Intercellular Calcium Waves and Gliosis in Rat Cortical Astrocytes

BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous $Aβ_{42}$ prompted by exogenous fibrillary or soluble $Aβ_{25–35}$ in human cortical astrocytes and neurons—Therapeutic relevance to Alzheimer's disease

Calcium-Sensing Receptor Antagonist NPS 2143 Restores Amyloid Precursor Protein Physiological Non-Amyloidogenic Processing in Aβ-Exposed Adult Human Astrocytes

The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death

Expression of vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor-β (PDGFR-β) in human gliomas

Exercise-induced changes of CSF vascular endothelial growth factor in adult chronic hydrocephalus patients

The Aβ Peptides-Activated Calcium-Sensing Receptor Stimulates the Production and Secretion of Vascular Endothelial Growth Factor-A by Normoxic Adult Human Cortical Astrocytes

Similar Documents

Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer's Disease

Amyloid β-Exposed Human Astrocytes Overproduce Phospho-Tau and Overrelease It within Exosomes, Effects Suppressed by Calcilytic NPS 2143—Further Implications for Alzheimer's Therapy

Amyloid β-Peptide Directly Induces Spontaneous Calcium Transients, Delayed Intercellular Calcium Waves and Gliosis in Rat Cortical Astrocytes

BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous $Aβ_{42}$ prompted by exogenous fibrillary or soluble $Aβ_{25–35}$ in human cortical astrocytes and neurons—Therapeutic relevance to Alzheimer's disease

Calcium-Sensing Receptor Antagonist NPS 2143 Restores Amyloid Precursor Protein Physiological Non-Amyloidogenic Processing in Aβ-Exposed Adult Human Astrocytes

The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death

Expression of vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor-β (PDGFR-β) in human gliomas

Exercise-induced changes of CSF vascular endothelial growth factor in adult chronic hydrocephalus patients

The Aβ Peptides-Activated Calcium-Sensing Receptor Stimulates the Production and Secretion of Vascular Endothelial Growth Factor-A by Normoxic Adult Human Cortical Astrocytes