NDLI: No association between a functional NAD(P)H : Quinone oxidoreductase gene polymorphism (Pro187Ser) and tardive dyskinesia

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NeuroMolecular Medicine : Volume 8, Issue 1-2, March 2006

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No association between a functional NAD(P)H : Quinone oxidoreductase gene polymorphism (Pro187Ser) and tardive dyskinesia

Content Provider	Springer Nature Link
Author	Hori, Hiroko Shinkai, Takahiro Matsumoto, Chima Ohmori, Osamu Nakamura, Jun
Copyright Year	2006
Abstract	Several lines of evidence have indicated that free radicals may play a role in the pathophysiology of tardive dyskinesia (TD) (reviewed in Andreassen and Jorgensen, 2000). NAD(P)H: quinone oxidoreductase (NQO1) is an important enzyme in the human body that counteracts the oxidative stress-induced neuronal injury caused by the toxic free radicals such as dopamine-semiquinones. Taking the possible genetic predisposition to TD into account (Yassa and Ananth, 1981), the NQO1 gene is a good candidate gene that may confer increased susceptibility to TD. Based on this hypothesis, Pae et al. (2004) reported a significant association between the Pro187Ser polymorphism in the NQO1 gene and TD. In the present study, we attempted to replicate the findings of Pae et al. (2004) with the same polymorphism in 222 Japanese patients with schizophrenia. No significant difference was detected between patients with and without TD in the allelic distribution (χ$^{2}$=0.070, d.f.=1,p=0.795) and in the genotypic distribution (χ$^{2}$=0.910,d.f.=2,p=0.657). In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the three genotype groups (p=0.49). Our results suggest that the NQO1 gene polymorphism does not confer an increased risk of TD.
Starting Page	375
Ending Page	380
Page Count	6
File Format	PDF
ISSN	15351084
Journal	NeuroMolecular Medicine
Volume Number	8
Issue Number	3
e-ISSN	15591174
Language	English
Publisher	Humana Press
Publisher Date	2006-01-01
Publisher Place	Totowa
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Medicine/Public Health Neurology Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Neurology Molecular Medicine Cellular and Molecular Neuroscience

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No association between a functional NAD(P)H : Quinone oxidoreductase gene polymorphism (Pro187Ser) and tardive dyskinesia