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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ekuni, D. Tomofuji, T. Irie, K. Azuma, T. Endo, Y. Kasuyama, K. Morita, M. |
| Copyright Year | 2011 |
| Abstract | Amyloid-β plays a causative role in Alzheimer’s disease. Occlusal disharmony causes chronic psychological stress, and psychological stress increases amyloid-β accumulation. The purpose of the present study was to investigate whether occlusal disharmony-induced psychological stress affects the accumulation of amyloid-β and its related gene expressions in the rat hippocampus. Eight-week-old male Wistar rats (n = 18) were divided into three groups of six rats each: (1) a control group that received no treatment for 8 weeks; (2) an occlusal disharmony group that underwent cutoff maxillary molar cusps for 8 weeks; and (3) a recovered group that underwent cutoff maxillary molar cusps for 4 weeks followed by recovery for 4 weeks. Occlusal disharmony increased plasma corticosterone levels in a time-dependent manner. Levels of amyloid-β 40 and 42, glucocorticoid receptor (Gr) protein, and cleaved caspase 3 (Casp3) as well as gene expressions of amyloid precursor protein, beta-secretase, Casp3, and Gr in the hippocampus in the occlusal disharmony group were significantly higher than those in the control group (P < 0.016). These findings were significantly improved by recovery of occlusion (P < 0.016). These results indicate that psychological stress induced by occlusal disharmony reversibly induces amyloid-β 40 and 42 in the rat hippocampus through the glucocorticoid signal. |
| Starting Page | 197 |
| Ending Page | 203 |
| Page Count | 7 |
| File Format | |
| ISSN | 15351084 |
| Journal | NeuroMolecular Medicine |
| Volume Number | 13 |
| Issue Number | 3 |
| e-ISSN | 15591174 |
| Language | English |
| Publisher | Humana Press Inc |
| Publisher Date | 2011-07-13 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Amyloid-beta Corticosterone Hippocampus Occlusion Psychological stress Neurology Internal Medicine Neurosciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Molecular Medicine Cellular and Molecular Neuroscience |
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