NDLI: A Transcriptional Roadmap to the Induction of Pluripotency in Somatic Cells

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A Transcriptional Roadmap to the Induction of Pluripotency in Somatic Cells

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Stem Cell Reviews and Reports : Volume 6, Issue 1, March 2010

Stem Cell Reviews and Reports : Volume 5

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Stem Cell Reviews and Reports : Volume 2

Stem Cell Reviews and Reports : Volume 1

A Transcriptional Roadmap to the Induction of Pluripotency in Somatic Cells

Content Provider	Springer Nature Link
Author	Wang, Ying Mah, Nancy Prigione, Alessandro Wolfrum, Katharina Andrade Navarro, Miguel A. Adjaye, James
Copyright Year	2010
Abstract	Human embryonic stem (ES) cells possess an enormous potential for applications in regenerative medicine. However, these cells have several inevitable hurdles limiting their clinical applications, such as transplant rejection and embryo destruction. A milestone recently achieved was the derivation of induced pluripotent stem (iPS) cells by over-expressing combinations of defined transcription factors, namely, OCT4, SOX2, NANOG, and LIN28 or OCT4, SOX2, KLF4, and c-MYC. Human iPS cells exhibit many characteristics identical to those of inner cell mass-derived ES cells. Here, we summarize the generation of human fibroblast-derived iPS cells and discuss the promises and limitations of their use. In addition, by utilising numerous published transcriptome datasets related to ES cells, fibroblast-derived iPS cells, partially induced pluripotent stem cells (PiPSC) and wild type fibroblasts, we reveal similarities (self-renewal signature) and differences (donor cell-type and PiPSC signatures) in genes and associated signaling pathways operative in the induction of pluripotency in fibroblasts. In particular, we highlight that induction of ground state pluripotency is also favoured by the inhibition of epithelial mesenchymal transition (EMT) and hence the induction of mesenchymal epithelial transition (MET). We anticipate that these findings might aid in the establishment of more efficient protocols for inducing pluripotency in somatic cells.
Starting Page	282
Ending Page	296
Page Count	15
File Format	PDF
ISSN	15508943
Journal	Stem Cell Reviews and Reports
Volume Number	6
Issue Number	2
e-ISSN	15586804
Language	English
Publisher	Humana Press Inc
Publisher Date	2010-03-25
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cellular reprogramming EMT MET Gene regulatory networks iPS cells ES cells PiPSC Self-renewal Pluripotency Cell Biology
Content Type	Text
Resource Type	Article
Subject	Medicine

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