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| Content Provider | Springer Nature Link |
|---|---|
| Author | Lo Iaco, Melania Anzalone, Rita La Rocca, Giampiero Baiamonte, Elena Maggio, Aurelio Acuto, Santina |
| Copyright Year | 2016 |
| Abstract | In recent years, umbilical cord blood (UCB) has been widely used as an alternative source to bone marrow (BM) for transplantation of hematopoietic stem and progenitor cells (HSPCs) in a variety of hematological and non-hematological disorders. Nevertheless, the insufficient number of UCB-HSPCs for graft represents a major challenge. HSPCs ex vivo expansion prior to transplantation is a valid strategy to overcome this limit. Several attempts to optimize the expansion conditions have been reported, including the use of mesenchymal stromal cells (MSCs) as feeder layer. Wharton’s Jelly (WJ), the main component of umbilical cord (UC) matrix, is especially rich in MSCs, which are considered ideal candidates for feeder layer in co-culture systems. In fact, they can be easily harvested and grow robustly in culture, producing a confluent monolayer in a short time. Similarly to bone marrow-mesenchymal stromal cells (BM-MSCs), WJ-derived MSCs (WJ-MSCs) have been used to support hematopoiesis in vitro and in vivo. Here, we review the rationale for using MSCs, particularly WJ-MSCs, as a feeder layer for UCB-HSPCs ex vivo expansion. In addition, we report the main findings attesting the use of these MSCs as a support in hematopoiesis. |
| Starting Page | 35 |
| Ending Page | 49 |
| Page Count | 15 |
| File Format | |
| ISSN | 15508943 |
| Journal | Stem Cell Reviews and Reports |
| Volume Number | 13 |
| Issue Number | 1 |
| e-ISSN | 15586804 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2016-11-16 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Wharton’s jelly mesenchymal stromal cells Hematopoietic and progenitor stem cells Ex vivo expansion Feeder layer Bone marrow transplantation Umbilical cord blood transplantation Stem Cells Regenerative Medicine/Tissue Engineering Cell Biology Biomedical Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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