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| Content Provider | Springer Nature Link |
|---|---|
| Author | Gomi, Kazuri Staudt, Michelle R. Salit, Jacqueline Kaner, Robert J. Heldrich, Jonna Rogalski, Allison M. Arbelaez, Vanessa Crystal, Ronald G. Walters, Matthew S. |
| Copyright Year | 2016 |
| Abstract | Basal cells (BC) are the stem/progenitor cells of the human airway epithelium capable of differentiating into secretory and ciliated cells. Notch signaling activation increases BC differentiation into secretory cells, but the role of individual Notch ligands in regulating this process in the human airway epithelium is largely unknown. The objective of this study was to define the role of the Notch ligand JAG1 in regulating human BC differentiation. JAG1 over-expression in BC increased secretory cell differentiation, with no effect on ciliated cell differentiation. Conversely, knockdown of JAG1 decreased expression of secretory cell genes. These data demonstrate JAG1-mediated Notch signaling regulates differentiation of BC into secretory cells. |
| Starting Page | 454 |
| Ending Page | 463 |
| Page Count | 10 |
| File Format | |
| ISSN | 15508943 |
| Journal | Stem Cell Reviews and Reports |
| Volume Number | 12 |
| Issue Number | 4 |
| e-ISSN | 15586804 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2016-05-23 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Notch signaling JAG1 Differentiation Human airway epithelium Basal stem/progenitor cells Stem Cells Regenerative Medicine/Tissue Engineering Cell Biology Biomedical Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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