NDLI: Calnexin, calreticulin, and ERp57 : Teammates in glycoprotein folding

Content Provider	Springer Nature Link
Author	Ellgaard, Lars Frickel, Eva Maria
Copyright Year	2003
Abstract	In eukaryotic cells, the endoplasmic reticulum (ER) plays an essential role in the synthesis and maturation of a variety of important secretory and membrane proteins. For glycoproteins, the ER possesses a dedicated maturation system, which assists folding and ensures the quality of final products before ER release. Essential components of this system include the lectin chaperones calnexin (CNX) and calreticulin (CRT) and their associated co-chaperone ERp57, a glycoprotein specific thiol-disulfide oxidoreductase. The significance of this system is underscored by the fact that CNX and CRT interact with practically all glycoproteins investigated to date, and by the debilitating phenotypes revealed in knockout mice deficient in either gene. Compared to other important chaperone systems, such as the Hsp70s, Hsp90s and GroEL/GroES, the principles whereby this system works at the molecular level are relatively poorly understood. However, recent structural and biochemical data have provided important new insights into this chaperone system and present a solid basis for further mechanistic studies.
Starting Page	223
Ending Page	247
Page Count	25
File Format	PDF
ISSN	10859195
Journal	Cell Biochemistry and Biophysics
Volume Number	39
Issue Number	3
e-ISSN	15590283
Language	English
Publisher	Humana Press
Publisher Date	2003-01-01
Publisher Place	Totowa
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biochemistry Pharmacology/Toxicology Biotechnology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Biochemistry Biophysics

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Role of cysteine amino acid residues in calnexin

Calnexin cycle - structural features of the ER chaperone system.

Enhanced Catalysis of Ribonuclease B Folding by the Interaction of Calnexin or Calreticulin with ERp57

Transient, highly populated, building blocks folding model

Overexpression of Calreticulin in Pre-eclamptic Placentas: Effect on Apoptosis, Cell Invasion and Severity of Pre-eclampsia

Folding funnels and conformational transitions via hinge-bending motions

Conformational Requirements for Glycoprotein Reglucosylation in the Endoplasmic Reticulum

Localization of the Lectin, ERp57 Binding, and Polypeptide Binding Sites of Calnexin and Calreticulin

A serendipitous discovery of antifreeze protein-specific activity in C-linked antifreeze glycoprotein analogs

Calnexin, calreticulin, and ERp57 : Teammates in glycoprotein folding

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