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| Content Provider | Springer Nature Link |
|---|---|
| Author | Jiang, Zhongyong Xiong, Jie |
| Copyright Year | 2014 |
| Abstract | Psoralen is a major active component of Psoralea corylifolia. In the present study, we analyzed psoralen-induced changes in human hepatocarcinoma cell viability and apoptosis, and investigated the underlying mechanisms of the proapoptotic effect of the compound on SMMC-7721 cells. We measured human hepatocarcinoma cell viability by MTT assay and Annexin V-FITC/PI double staining, and evaluated the activity of caspase 3 and the expression of p53, Bax, and Bcl-2 proteins, involved in regulating cell apoptosis. Psoralen was able to inhibit the growth of SMMC-7721 cells in a dose- and time-dependent manner and had a strong proapoptotic effect on these cells. We show a dose-dependent increase in caspase-3 activity, and elevated levels of p53 and Bax proteins in psoralen-treated cells, that coincided with dose-dependent decrease in Bcl-2 expression. These results suggest that psoralen induces apoptosis in cancer cells via mechanisms that involve caspase-3, p53, Bax, and Bcl-2 pathway. Our results may provide a molecular basis for the further development of natural compounds as novel anticancer agents for human hepatomas. |
| Starting Page | 1075 |
| Ending Page | 1081 |
| Page Count | 7 |
| File Format | |
| ISSN | 10859195 |
| Journal | Cell Biochemistry and Biophysics |
| Volume Number | 70 |
| Issue Number | 2 |
| e-ISSN | 15590283 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2014-05-21 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Psoralen SMMC-7721 cell Apoptosis Caspase-3 p53 Bax Bcl-2 Biochemistry Pharmacology/Toxicology Biotechnology Cell Biology Biophysics and Biological Physics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Biochemistry Biophysics |
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