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| Content Provider | Springer Nature Link |
|---|---|
| Author | Li, Xueping Li, Jianan Cheng, Kai Lin, Qiang Wang, Daxin Zhang, Hongfei An, Hengyuan Gao, Mingxia Chen, Anliang |
| Copyright Year | 2011 |
| Abstract | We evaluated the effect of low-intensity pulsed ultrasound (LIPUS) on MMP-13 and MAPKs expression in rabbit knee osteoarthritis (OA). For this purpose, 18 New Zealand white rabbits were randomly and equally divided into O + L, O – L, and SO groups. In O + L group, animals underwent right back leg ACLT operation and LIPUS radiation. In O − L group, animals underwent ACLT but no LIPUS treatment. In SO (control) group, animals underwent sham operation without LIPUS. After 6 weeks, we assessed the pathologic changes in the articular surface of femoral condyle and compared using Mankin scores. Also, expression of type-II collagen, MMP-13, ERK1/2, p38, and JNK was measured by Western blot. Compared with controls, Mankin scores were higher in O + L (P < 0.05)/O − L (P < 0.01) groups. Compared with O + L group, score was higher in O − L group (P < 0.05). Compared with controls, type-II collagen expression was less in O + L/O − L groups, with more significant decrease in O − L group (P < 0.05). Contrarily, expression of MMP-13, p-ERK1/2, and p-p38 was enhanced in O + L/O − L groups as compared with controls, with more significant increase in O − L group (P < 0.01). Compared with O + L group, expression was higher in O − L group (P < 0.05). We, therefore, concluded that LIPUS application promoted cartilage repair in OA through the downregulation of MMP-13, ERK1/2, and p38. |
| Starting Page | 427 |
| Ending Page | 434 |
| Page Count | 8 |
| File Format | |
| ISSN | 10859195 |
| Journal | Cell Biochemistry and Biophysics |
| Volume Number | 61 |
| Issue Number | 2 |
| e-ISSN | 15590283 |
| Language | English |
| Publisher | Humana Press Inc |
| Publisher Date | 2011-05-13 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Osteoarthritis Articular cartilage Rabbit LIPUS MMP-13 MAPK ACLT Pharmacology/Toxicology Biophysics and Biological Physics Cell Biology Biotechnology Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Biochemistry Biophysics |
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