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  1. Cell Biochemistry and Biophysics
  2. Cell Biochemistry and Biophysics : Volume 67
  3. Cell Biochemistry and Biophysics : Volume 67, Issue 1, September 2013
  4. Neuronal Ubiquitin Homeostasis
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Cell Biochemistry and Biophysics : Volume 75
Cell Biochemistry and Biophysics : Volume 74
Cell Biochemistry and Biophysics : Volume 73
Cell Biochemistry and Biophysics : Volume 72
Cell Biochemistry and Biophysics : Volume 71
Cell Biochemistry and Biophysics : Volume 70
Cell Biochemistry and Biophysics : Volume 69
Cell Biochemistry and Biophysics : Volume 68
Cell Biochemistry and Biophysics : Volume 67
Cell Biochemistry and Biophysics : Volume 67, Issue 3, December 2013
Cell Biochemistry and Biophysics : Volume 67, Issue 2, November 2013
Cell Biochemistry and Biophysics : Volume 67, Issue 1, September 2013
Ubiquitin and Drug Discovery: Challenges and Opportunities
Selective Autophagy: Talking with the UPS
Regulators and Effectors of Siah Ubiquitin Ligases
Deubiquitylating Enzymes and DNA Damage Response Pathways
Could Dysregulation of UPS be a Common Underlying Mechanism for Cancer and Neurodegeneration? Lessons from UCHL1
Regulating the Ubiquitin/Proteasome Pathway Via cAMP-signaling: Neuroprotective Potential
Neuronal Ubiquitin Homeostasis
Measuring Activity in the Ubiquitin–Proteasome System: From Large Scale Discoveries to Single Cells Analysis
Activity-Based Imaging Probes of the Proteasome
Biochemical and Structural Characterization of the Ubiquitin-Conjugating Enzyme UBE2W Reveals the Formation of a Noncovalent Homodimer
The WD40-Repeat Protein-Containing Deubiquitinase Complex: Catalysis, Regulation, and Potential for Therapeutic Intervention
Diggin′ on U(biquitin): A Novel Method for the Identification of Physiological E3 Ubiquitin Ligase Substrates
Absolute Quantification of E1, Ubiquitin-Like Proteins and Nedd8–MLN4924 Adduct by Mass Spectrometry
Inhibition of Protein Deubiquitination by PR-619 Activates the Autophagic Pathway in OLN-t40 Oligodendroglial Cells
Comprehensive Ubiquitin E2 Profiling of Ten Ubiquitin E3 Ligases
Efficacy of Repetitive Transcranial Magnetic Stimulation in the Treatment of Patients with Chronic Primary Insomnia
A Relationship Between Replication Protein A and Occurrence and Prognosis of Esophageal Carcinoma
Effect of Arborvitae Seed on Cognitive Function and α7nAChR Protein Expression of Hippocampus in Model Rats with Alzheimer’s Disease
Novel c.2216T > C (p.I739T) Mutation in Exon 13 and c.1481T > A (p.L494X) Mutation in Exon 8 of MUT Gene in a Female with Methylmalonic Acidemia
Icariin Protects Against Glucocorticoid-Induced Osteoporosis In Vitro and Prevents Glucocorticoid-Induced Osteocyte Apoptosis In Vivo
Gambogic Acid Sensitizes Ovarian Cancer Cells to Doxorubicin Through ROS-Mediated Apoptosis
Experimental Research on the In Vitro Antitumor Effects of Crataegus sanguinea
Cell Biochemistry and Biophysics : Volume 66
Cell Biochemistry and Biophysics : Volume 65
Cell Biochemistry and Biophysics : Volume 64
Cell Biochemistry and Biophysics : Volume 63
Cell Biochemistry and Biophysics : Volume 62
Cell Biochemistry and Biophysics : Volume 61
Cell Biochemistry and Biophysics : Volume 60
Cell Biochemistry and Biophysics : Volume 59
Cell Biochemistry and Biophysics : Volume 58
Cell Biochemistry and Biophysics : Volume 57
Cell Biochemistry and Biophysics : Volume 56
Cell Biochemistry and Biophysics : Volume 55
Cell Biochemistry and Biophysics : Volume 54
Cell Biochemistry and Biophysics : Volume 53
Cell Biochemistry and Biophysics : Volume 52
Cell Biochemistry and Biophysics : Volume 51
Cell Biochemistry and Biophysics : Volume 50
Cell Biochemistry and Biophysics : Volume 49
Cell Biochemistry and Biophysics : Volume 48
Cell Biochemistry and Biophysics : Volume 47
Cell Biochemistry and Biophysics : Volume 46
Cell Biochemistry and Biophysics : Volume 45
Cell Biochemistry and Biophysics : Volume 44
Cell Biochemistry and Biophysics : Volume 43
Cell Biochemistry and Biophysics : Volume 42
Cell Biochemistry and Biophysics : Volume 41
Cell Biochemistry and Biophysics : Volume 40
Cell Biochemistry and Biophysics : Volume 39
Cell Biochemistry and Biophysics : Volume 38
Cell Biochemistry and Biophysics : Volume 37
Cell Biochemistry and Biophysics : Volume 36
Cell Biochemistry and Biophysics : Volume 35
Cell Biochemistry and Biophysics : Volume 34
Cell Biochemistry and Biophysics : Volume 33
Cell Biochemistry and Biophysics : Volume 32
Cell Biochemistry and Biophysics : Volume 31
Cell Biochemistry and Biophysics : Volume 30
Cell Biochemistry and Biophysics : Volume 29
Cell Biochemistry and Biophysics : Volume 28
Cell Biochemistry and Biophysics : Volume 27

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Neuronal Ubiquitin Homeostasis

Content Provider Springer Nature Link
Author Hallengren, Jada Chen, Ping Chung Wilson, Scott M.
Copyright Year 2013
Abstract Neurons have highly specialized intracellular compartments that facilitate the development and activity of the nervous system. Ubiquitination is a post-translational modification that controls many aspects of neuronal function by regulating protein abundance. Disruption of this signaling pathway has been demonstrated in neurological disorders such as Parkinson’s disease, Amyotrophic Lateral Sclerosis and Angleman Syndrome. Since many neurological disorders exhibit ubiquitinated protein aggregates, the loss of neuronal ubiquitin homeostasis may be an important contributor of disease. This review discusses the mechanisms utilized by neurons to control the free pool of ubiquitin necessary for normal nervous system development and function as well as new roles of protein ubiquitination in regulating the synaptic activity.
Starting Page 67
Ending Page 73
Page Count 7
File Format PDF
ISSN 10859195
Journal Cell Biochemistry and Biophysics
Volume Number 67
Issue Number 1
e-ISSN 15590283
Language English
Publisher Springer US
Publisher Date 2013-05-18
Publisher Place Boston
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Ubiquitin Proteasome Synapse Deubiquitinating Enzymes Biochemistry Pharmacology/Toxicology Biotechnology Cell Biology Biophysics and Biological Physics
Content Type Text
Resource Type Article
Subject Cell Biology Medicine Biochemistry Biophysics
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