NDLI: Fabp3 Inhibits Proliferation and Promotes Apoptosis of Embryonic Myocardial Cells

Content Provider	Springer Nature Link
Author	Zhu, C. Hu, D. L. Liu, Y. Q. Zhang, Q. J. Chen, F. K. Kong, X. Q. Cao, K. J. Zhang, J. S. Qian, L. M.
Copyright Year	2011
Abstract	Fatty acid binding protein 3 (FABP3) is a member of a family of binding proteins. The protein is mainly expressed in cardiac and skeletal muscle cells, and it has been linked to fatty acid metabolism, trafficking, and signaling. Using suppression subtractive hybridization, we previously found that FABP3 is highly regulated in ventricular septal defect (VSD) patients and may play a significant role in the development of human VSD. We therefore aimed to identify the biological characteristics of the FABP3 gene in embryonic myocardial cells. On the basis of RT-PCR and western blotting analyses, we demonstrated that the expression levels of FABP3 mRNA and protein were up-regulated initially and then gradually decreased with P19 cell differentiation. MTT assays and cell cycle analysis showed that FABP3 inhibits P19 cell proliferation, and data from annexin V-FITC assays revealed that FABP3 can promote apoptosis of P19 cells. Further data from quantitative real-time RT-PCR revealed lower expression levels of cardiac muscle-specific molecular markers (cTnT, alpha-MHC, GATA4, and MEF2c) in FABP3-overexpressing cell lines than in the control cells during differentiation. Our results demonstrate that FABP3 may be involved in the differentiation of cardiac myocytes.
Starting Page	259
Ending Page	266
Page Count	8
File Format	PDF
ISSN	10859195
Journal	Cell Biochemistry and Biophysics
Volume Number	60
Issue Number	3
e-ISSN	15590283
Language	English
Publisher	Humana Press Inc
Publisher Date	2011-02-04
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	CHD LYRM1 P19 cells Heart development Biophysics and Biological Physics Pharmacology/Toxicology Biochemistry Cell Biology Biotechnology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Biochemistry Biophysics

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