NDLI: Cerebral Hemorrhage Increases Plasma Concentrations of Noradrenalin and Creatine Kinase MB Fraction with Induction of Cardiomyocyte Damage in Rats

Content Provider	Springer Nature Link
Author	Liang, Xiao Min Chen, Jia Zhang, Tao Liu, Juan Jiang, Xiao Jiang Xu, Zhi Qiang
Copyright Year	2014
Abstract	The incidence of cardiac damage is high during acute cerebral hemorrhage. The animal data on the relationship between cerebral apoplexy and cardiac damage are lacking. Thus, the aim of the study was to evaluate the effects of cerebral hemorrhage on plasma concentrations of monoamine transmitter noradrenalin (NA), creatine kinase muscle and brain (CK-MB) isoenzyme fraction, and cardiomyocyte changes in the rat model. In this study, 140 Wistar rats were randomly and equally divided into experimental and control groups, and collagenase was injected into the right caudate nucleus to induce cerebral hemorrhage in the experimental group. Plasma NA was analyzed using high-performance liquid chromatography with electrochemical detection and serum CK-MB was measured by enzyme reaction rate method. We found that both NA and CK-MB were elevated (p < 0.05) at 6 h after cerebral hematoma formation; the levels were 2.46 ± 0.05 μg/L and 3.51 ± 0.23 μkat/L, respectively. NA and CK-MB concentrations reached peak levels at 24 h which were found to be 3.52 ± 0.06 μg/L and 5.47 ± 0.49 μkat/L, respectively. Thereafter, NA and CK-MB concentrations decreased gradually. Plasma NA declined to the preoperative level (1.66 ± 0.03 μg/L) at 72 h, while CK-MB level (2.71 ± 0.17 μkat/L) was found to be still higher than its preoperative level. It was, therefore, concluded that plasma NA might be involved in the induction and development of cardiomyocytes damage during cerebral hemorrhage.
Starting Page	1807
Ending Page	1811
Page Count	5
File Format	PDF
ISSN	10859195
Journal	Cell Biochemistry and Biophysics
Volume Number	70
Issue Number	3
e-ISSN	15590283
Language	English
Publisher	Springer US
Publisher Date	2014-07-15
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cerebral hemorrhage Cardiomyocyte Noradrenalin Creatine kinase MB Biochemistry Pharmacology/Toxicology Biotechnology Cell Biology Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Biochemistry Biophysics

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