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| Content Provider | Springer Nature Link |
|---|---|
| Author | Wang, Jie Lan, Zuoping Zhang, Li Guo, Hongmei Liu, Zhonghong Yu, Yu |
| Copyright Year | 2015 |
| Abstract | In this study, a more rapid and more sensitive ultra performance liquid chromatography-tandem mass spectrometry (UPLC–MS/MS) method is developed and validated for the pharmacokinetic study of a new lung-targeting docetaxel liposome (DTX-LP) at low dose (1 mg/kg) in rabbits. The method is reliable and reproducible with intra-day precision below 5.75 %, inter-day precision below 7.57 %, and mean extraction recovery of 84.1–91.7 %. At low dose, the validated method is successfully applied to the comparative pharmacokinetic study of docetaxel (DTX) in rabbit plasma after intravenous administration of DTX-LP and DTX injection, respectively. The results indicate that the pharmacokinetic profile of DTX is completely changed when loaded in the new type of liposome, which can make DTX quicker distribution from the circulation to the target organ and slower eliminated from the body. |
| Starting Page | 623 |
| Ending Page | 629 |
| Page Count | 7 |
| File Format | |
| ISSN | 10859195 |
| Journal | Cell Biochemistry and Biophysics |
| Volume Number | 73 |
| Issue Number | 3 |
| e-ISSN | 15590283 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2015-05-24 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Docetaxel UPLC–MS/MS Pharmacokinetics Lung-targeting Liposome Biochemistry Pharmacology/Toxicology Biotechnology Cell Biology Biophysics and Biological Physics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Biochemistry Biophysics |
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