NDLI: Inflammatory Lesions of Cochlea in Murine Cytomegalovirus-Infected Mice with Hearing Loss

Content Provider	Springer Nature Link
Author	Yuehua, Qiao Longzhen, Zhang Kailin, Xu Lingyu, Zeng Lingjian, Meng Jun, Wang Hong, Meng
Copyright Year	2011
Abstract	We sought to determine the distribution of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and lymphocytes in the cochlea of mice infected with murine cytomegalovirus (MCMV). For this purpose, 16 newborn mice were divided equally into model and control (uninfected) groups. In model group, 10 μl of MCMV was injected into the brain of each mouse whereas in control group, 10 μl of physiological saline was injected. Fourteen days after the injection of MCMV, the auditory brainstem response audiometry was performed. Later, the mice were killed and the acoustic capsule samples were collected for polymerase chain reaction analysis, histopathological and immunohistochemical studies. Compared with control mice, the incubation period was longer (F = 13.797; P = 0.003) and the amplitude was lower (F = 5.095; P = 0.043) in model group mice. It indicated that the intracerebral injection of MCMV caused hearing loss in mice. Histopathological examination of cochleas revealed increased levels of lymphocytic infiltration in the membrana vestibularis. Higher levels of TNF-α and IL-6 in scala tympani were detected by immunohistochemical staining. Taken together, the hearing loss in mice could be related with the inflammatory changes occurring in cochlea after inception of MCMV infection.
Starting Page	281
Ending Page	287
Page Count	7
File Format	PDF
ISSN	10859195
Journal	Cell Biochemistry and Biophysics
Volume Number	62
Issue Number	2
e-ISSN	15590283
Language	English
Publisher	Humana Press Inc
Publisher Date	2011-10-15
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Murine cytomegalovirus Cochlear inflammation Hearing loss Tumor necrosis factor (TNF)-α Interleukin (IL)-6 Cell Biology Biotechnology Pharmacology/Toxicology Biochemistry Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Biochemistry Biophysics

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