NDLI: H$_{2}$O$_{2}$ Induces Myocardial Hypertrophy in H9c2 Cells: A Potential Role of Ube3a

Content Provider	Springer Nature Link
Author	Song, Rui Zhang, Jie Zhang, Lijuan Wang, Guanghua Wo, Da Feng, Jian Li, Xucheng Li, Jue
Copyright Year	2014
Abstract	Myocardial hypertrophy that often leads to eventual heart failure is a leading cause of mortality worldwide. While both apoptosis and cell proliferation have been reported to play an important part in heart failure, its exact triggering mechanism is still unclear. Reports have shown that low concentrations of H$_{2}$O$_{2}$ (10–30 µM) can induce myocardial hypertrophy without affecting survival. The ubiquitin ligase Ube3a has been reported to have a close affiliation with Angelman syndrome; but many ubiquitin ligases have been reported in a variety of cardiovascular conditions including myocardial hypertrophy. However, the relationship between Ube3a and myocardial hypertrophy has never been reported in literature. The rat cardiac myoblast cell line H9c2 and primary neonatal cardiomyocytes showed similar hypertrophic responses in vitro. In this report, we utilized H$_{2}$O$_{2}$ treatment on H9c2 cells to induce myocardial hypertrophy and determined the relationship between Ube3a and myocardial hypertrophy. Our results showed that 10–20 μM H$_{2}$O$_{2}$ can induce myocardial hypertrophy without affecting cell viability and inducing cell apoptosis, while the corresponding transcription and translation levels of Ube3a are significantly increased during the process. Therefore, these findings underline that Ube3a may play an important role in myocardial hypertrophy.
Starting Page	23
Ending Page	28
Page Count	6
File Format	PDF
ISSN	15307905
Journal	Cardiovascular Toxicology
Volume Number	15
Issue Number	1
e-ISSN	15590259
Language	English
Publisher	Springer US
Publisher Date	2014-06-11
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	H$_{2}$O$_{2}$ Ube3a Myocardial hypertrophy Ubiquitin Pharmacology/Toxicology Cardiology
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Toxicology Cardiology and Cardiovascular Medicine

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