NDLI: Preventive Effects of Egyptian Sweet Marjoram (Origanum majorana L.) Leaves on Haematological Changes and Cardiotoxicity in Isoproterenol-Treated Albino Rats

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Preventive Effects of Egyptian Sweet Marjoram (Origanum majorana L.) Leaves on Haematological Changes and Cardiotoxicity in Isoproterenol-Treated Albino Rats

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Cardiovascular Toxicology : Volume 13, Issue 1, March 2013

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Preventive Effects of Egyptian Sweet Marjoram (Origanum majorana L.) Leaves on Haematological Changes and Cardiotoxicity in Isoproterenol-Treated Albino Rats

Content Provider	Springer Nature Link
Author	Ramadan, Gamal El Beih, Nadia M. Arafa, Nadia M. S. Zahra, Mai M.
Copyright Year	2012
Abstract	We made an attempt to evaluate/compare the cardioprotective activity of two different doses (50 and 100 mg/kg body weight, given orally for 30 consecutive days) of Egyptian sweet marjoram leaf powder (MLP) and marjoram leaf aqueous extract (MLE) against isoproterenol (ISO)-induced myocardial infarcted rats (150 mg/kg body weight, twice at an interval of 24 h on days 29 and 30). The present study showed (probably for the first time) that both MLP and MLE (especially the high dose) significantly alleviated (P < 0.05–0.001) erythrocytosis, granulocytosis, thrombocytosis, shortened clotting time, the increase in relative heart weight, myocardial oxidative stress and the leakage of heart enzymes (creatine phosphokinase (CPK), CPK–MB isoenzyme, lactate dehydrogenase and aminotransferase) in ISO-treated rats through reactivating non-enzymic (reduced glutathione) and enzymic (catalase, glutathione peroxidase, glutathione S-transferase, superoxide dismutase) antioxidant defence system and inhibiting the production of nitric oxide and lipid peroxidation in heart tissues. The modulatory effects of marjoram leaves shown in the present study were dose-dependent in most cases and much higher in MLE (4.3–20.3 % for all parameters taken together). In addition, the doses used in the present study were considered safe. In conclusion, this study may have a significant impact on myocardial infarcted patients.
Starting Page	100
Ending Page	109
Page Count	10
File Format	PDF
ISSN	15307905
Journal	Cardiovascular Toxicology
Volume Number	13
Issue Number	2
e-ISSN	15590259
Language	English
Publisher	Humana Press Inc
Publisher Date	2012-10-10
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Albino rats Antioxidant activity Cardiotoxicity Haematological changes Isoproterenol Origanum majorana Pharmacology/Toxicology Cardiology
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Toxicology Cardiology and Cardiovascular Medicine

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