NDLI: Analysis of the Albumin cobalt Binding (ACB$^{TM}$) test as an adjunct to cardiac troponin I for the early detection of acute myocardial infarction

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Improved identification of acute coronary syndromes with delta cardiac serum marker measurements during the emergency department evaluation of chest pain patients

Rationale for the early clinical application of markers of ischemia in patients with suspected acute coronary syndromes

Clinical and pathobiologic considerations in the evaluation of markers of myocardial ischemia

Markers of platelet activation and thrombin generation

Analysis of the Albumin cobalt Binding (ACB$^{TM}$) test as an adjunct to cardiac troponin I for the early detection of acute myocardial infarction

C-reactive protein and coronary heart disease : Diagnostic and therapeutic implications for primary prevention

B-type natriuretic peptide levels : Diagnostic and therapeutic potential

Mammalian cardenolides as biomarkers in congestive heart failure

Determination of the falloff constant (k $_{ f }$) from modeling biochemical marker release : A new variable for discriminating therapies

Cardiovascular Toxicology : Volume 1, Issue 1, March 2001

Analysis of the Albumin cobalt Binding (ACB$^{TM}$) test as an adjunct to cardiac troponin I for the early detection of acute myocardial infarction

Content Provider	Springer Nature Link
Author	Wu, Alan H. B. Morris, Deborah L. Fletcher, Dana R. Apple, Fred S. Christenson, Robert H. Painter, Pennell C.
Copyright Year	2001
Abstract	Human albumin has the ability to bind cobalt at the N-terminus. The exposure of circulating albumin to ischemic tissue alters the ability of albumin to bind cobalt, probably through a mechanism involving free-radical production. The Albumin Cobalt Binding (ACB$^{TM}$) test measures the alteration in albumin metal binding, and elevation of the ACB test is thought to be an early indicator of myocardial ischemia. In a previous multicenter study of chest pain patients presenting to the emergency department (ED), this test demonstrated high negative predictive value and sensitivity in the sample collected at presentation for predicting cardiac troponin I (cTnl)-negative or cTnl-positive results 6–24 h later. Since the completion of that report, the European Society of Cardiology (ESC) and the American College of Cardiology (ACC) have redefined the criteria for the diagnosis of acute myocardial infarction (AMI). The data from the multicenter ACB study were re-examined using the new diagnostic criteria for AMI to determine if combining the ACB test with troponin improved the sensitivity of either assay used alone for early diagnosis of AMI. Assay values were compared to either the final discharge diagnosis made at each site or to a diagnosis of AMI using the strict application of the ESC/ACC guidelines. Using the criterion of physician's discharge diagnosis and using blood collected at ED presentation, the cTnl test alone had a sensitivity of 23.9%, and the ACB test alone had a sensitivity of 39.1%, but the sensitivity significantly increased to 55.9% (p<0.001 over cTnl alone) when both tests were used in combination. The sensitivity of the combination of ACB and cTnl tests at the 1- to 6-h time-point was 86.7% and at the >6- to 12-h time-point was 93.5%, but they were not significantly improved over the cTnl test alone. In conclusion, using the new ESC/ACC criteria, the combination also resulted in a statistically significant higher diagnostic sensitivity on blood collected at presentation. These data indicate a possible role of the ACB test in the early triage of patients with chest pain.
Starting Page	147
Ending Page	151
Page Count	5
File Format	PDF
ISSN	15307905
Journal	Cardiovascular Toxicology
Volume Number	1
Issue Number	2
e-ISSN	15590259
Language	English
Publisher	Humana Press
Publisher Date	2001-01-01
Publisher Place	Totowa
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Albumin Cobalt Binding test acute myocardial infarction cardiac troponin I myocardial ischemia Pharmacology/Toxicology Cardiology
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Toxicology Cardiology and Cardiovascular Medicine

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Analysis of the Albumin cobalt Binding (ACB$^{TM}$) test as an adjunct to cardiac troponin I for the early detection of acute myocardial infarction

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