NDLI: The balance between pro-apoptotic and anti-apoptotic pathways in the failing myocardium

Content Provider	Springer Nature Link
Author	McGowan, Brian S. Ciccimaro, Eugene F. Chan, Tung O. Feldman, Arthur M.
Copyright Year	2003
Abstract	The purpose of this review is to highlight those circulating molecules, membrane receptors, and signaling pathways that initiate, potentiate, or conversely, inhibit apoptosis within cardiomyocytes. This review focuses on pathways directly related to the failing heart and discusses the limitations of current methodologies for assessing cardiomyocellular apoptosis. It is important to note that the adrenergic, reactive oxygen species, and proinflammatory cytokine signaling pathways are not the only pro-apoptotic pathways active in the myocardium, nor are IL-6-related cytokine, calcineurin, and IGF-1/P13K/Akt signaling pathways the only anti-apoptotic pathways active in the myocardium. However, the are among the best-characterized apoptosis-mediating pathways and therefore they may serve as foundation for future studies aimed at identifying novel apoptotic regulating pathways active in cardiomyocytes.Considering the short history of studying cardiomyocellular apoptosis, a tremendous body of knowledge has been collected. Understandably, much more work remains. Tomorrow’s studies must (1) continue to examine the signaling pathways mediating cardiomyocellular apoptosis by focusing on the links to the ubiquitous apoptosis effectors, (2) use the expanding body of knowledge to develop more specific inhibitors of apoptosis, and then (3) confirm the causal relationship of cardiomyocellular apoptosis and cardiac dysfunction in physiologic models of cardiac challenge.
Starting Page	191
Ending Page	205
Page Count	15
File Format	PDF
ISSN	15307905
Journal	Cardiovascular Toxicology
Volume Number	3
Issue Number	3
e-ISSN	15590259
Language	English
Publisher	Humana Press
Publisher Date	2003-01-01
Publisher Place	Totowa
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cardiomyocyte apoptosis models methods limitations Pharmacology/Toxicology Cardiology
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Toxicology Cardiology and Cardiovascular Medicine

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