NDLI: Protective Effect of Porcine Cerebral Hydrolysate Peptides on Learning and Memory Deficits and Oxidative Stress in Lead-Exposed Mice

Content Provider	Springer Nature Link
Author	Zou, Ye Feng, Weiwei Wang, Wei Chen, Yao Zhou, Zhaoxiang Li, Qian Zhao, Ting Mao, Guanghua Wu, Xiangyang Yang, Liuqing
Copyright Year	2015
Abstract	In this study, lead acetate solution and porcine cerebral hydrolysate peptides (PCHPs) were administered to developing mice. Porcine cerebral protein pretreated by ultrasound was hydrolyzed with alcalase, and 11 peptide fragments were obtained by Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis of PCHPs. Our data showed that PCHPs significantly decreased Pb$^{2+}$-induced spontaneous locomotor activity, latencies to reach the platform, and the time in target quadrant. It also decreased the accumulation of lead in the blood and brain of Pb$^{2+}$-exposed developing mice. Co-administration of PCHPs and dimercaptosuccinic acid (DMSA) did not only reduce the accumulation of lead in blood but also increased the absorption of zinc and iron in Pb$^{2+}$-exposed mice. Administration of PCHPs individually significantly enhanced hematopoietic parameters compared with the Pb$^{2+}$-exposed group. PCHPs significantly reduced the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) but increased glutathione (GSH) content and anti-oxidant enzymes and nitric oxide synthase (NOS) activities in Pb$^{2+}$-exposed brain. Our findings suggest that PCHPs have the ability to protect against Pb$^{2+}$-exposed learning and memory deficits and oxidative damage.
Starting Page	429
Ending Page	440
Page Count	12
File Format	PDF
ISSN	01634984
Journal	Biological Trace Element Research
Volume Number	168
Issue Number	2
e-ISSN	15590720
Language	English
Publisher	Springer US
Publisher Date	2015-05-10
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Porcine cerebral hydrolysate peptides Lead Learning and memory deficits Oxidative stress NOS Biochemistry Biotechnology Nutrition Oncology
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Inorganic Chemistry

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