NDLI: Serum Arsenic and Lipid Peroxidation Levels in Patients with Multiple Sclerosis

Content Provider	Springer Nature Link
Author	Yousefi, Bahman Ahmadi, Yasin Ghorbanihaghjo, Amir Faghfoori, Zeinab irannejad, Vahid Shafiei
Copyright Year	2014
Abstract	Oxidative stress plays a crucial role in the pathogenesis of multiple sclerosis (MS). Previous studies have shown that oxidative stress is one of the main underlying mechanisms of arsenic-induced cellular damage. The aim of this study was to assess the serum levels of arsenic and its relationship with lipid peroxidation in MS patients from Tabriz, as the third polluted city of Iran. The study population included 38 MS female patients and 38 age-matched healthy controls. Serum malondialdehyde (MDA) and arsenic levels were measured using thiobarbituric acid reactive substances (TBARS) assay and electrothermal atomic absorption spectrometry, respectively. The results showed that the arsenic (P < 0.01) and MDA (P = 0.03) levels were significantly higher in patients with MS than those in control. Moreover, serum levels of arsenic and MDA were positively correlated in MS patients. The elevated levels of serum arsenic might explain the increased oxidative stress in MS patients. We suggest that high arsenic levels in serum may lead to MS development, and therefore, exposure to this metal should be limited.
Starting Page	276
Ending Page	279
Page Count	4
File Format	PDF
ISSN	01634984
Journal	Biological Trace Element Research
Volume Number	158
Issue Number	3
e-ISSN	15590720
Language	English
Publisher	Springer US
Publisher Date	2014-04-10
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neurodegenerative Multiple sclerosis Oxidative stress Malondialdehyde Heavy metal Arsenic Biochemistry Biotechnology Nutrition Oncology
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Inorganic Chemistry

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