NDLI: Psychological Stress Expands Low Molecular Weight Iron Pool in Cerebral Cortex, Hippocampus, and Striatum of Rats

Content Provider	Springer Nature Link
Author	Huang, Kai Li, Hongxia Shen, Hui Li, Min
Copyright Year	2011
Abstract	We have previously demonstrated that psychological stress (PS) can cause iron to accumulate in the cerebral cortex, hippocampus, and striatum of rats. However, why iron accumulates and in what oxidation state iron it accumulates in the brain of PS-exposed rats has not been well elucidated. In the present study, we investigated the influence of PS on the low molecular weight iron pool (LMWIP) in the rat brain. The results showed that: (1) PS significantly expanded LMWIP in the cerebral cortex, hippocampus, and striatum in rats; (2) PS caused derangement of pyramidal cells and reduced the layers of pyramidal CA1 and CA2 neurons; (3) PS exposure greatly lowered the expression of ferritin (Fn) and hephaestin (HP) in the rat cortex and hippocampus; and (4) PS decreased superoxide dismutase, glutathione peroxidase, and glutathione level and increased malondialdehyde level in the cerebral cortex, hippocampus, and striatum in rats. These results indicated that PS could expand LMWIP significantly, which may be attributed to PS-induced decrease in Fn, HP expression, and the subsequent reduction in iron storage and utilization, and expansion of LMWIP could in turn lead to aggravation of oxidative damage.
Starting Page	79
Ending Page	85
Page Count	7
File Format	PDF
ISSN	01634984
Journal	Biological Trace Element Research
Volume Number	146
Issue Number	1
e-ISSN	15590720
Language	English
Publisher	Humana Press Inc
Publisher Date	2011-10-13
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Psychological stress Low molecular weight iron Iron overload Hephaestin Oxidative stress Biochemistry Oncology Biotechnology Nutrition
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Inorganic Chemistry

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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