NDLI: Effect of Increasing Concentrations of Zinc on the Absorption of Iron from Iron-Fortified Milk

Content Provider	Springer Nature Link
Author	Olivares, Manuel Wiedeman, Alejandra Bolívar, Lorena López de Romaña, Daniel Pizarro, Fernando
Copyright Year	2012
Abstract	The cofortification of milk with iron (Fe) and zinc (Zn) is a strategy used to prevent these deficiencies during childhood. Given that Zn can negatively interact with iron in aqueous solutions, the objective of the present study was to determine the effect of Zn on Fe absorption of milk fortified with Fe and Zn. Twenty-eight women between 33 and 47 years of age, with contraception and a negative pregnancy test, participated in one of two absorption studies. They received on four different days, after an overnight fast, 200 mL of milk (26 % fat) fortified with 10 mg Fe/L, as (A) ferrous sulfate, or the same milk but with graded doses of added Zn, as Zn sulfate of (B) 5, (C) 10, and (D) 20 mg/L (study 1, n = 15). In study 2 (n = 13), subjects received the same milk formulations, but these were also fortified with ascorbic acid (70 mg/L). Milk was labeled with radioisotopes $^{59}$Fe or $^{55}$Fe, and the absorption of iron was measured by erythrocyte incorporation of radioactive Fe. The geometric mean and range of ±1 SD of Fe absorption in study 1 were as follows: formula A = 6.0 % (2.8–13.0 %); B = 6.7 % (3.3–13.6 %); C = 5.4 % (2.2–13.2 %); and D = 5.2 % (2.8–10.0 %) (ANOVA for repeated measures, not significant). For study 2, data are as follows: 8.2 % (3.6–18.7 %); B = 6.4 % (2.5–16.4 %); C = 7.7 % (3.2–18.9 %); and D = 5.2 (1.8–14.8 %) (ANOVA for repeated measures, not significant). In conclusion, according to the results from this study, it appears that the addition of zinc up to 20 mg/L does not significantly inhibit iron absorption from milk fortified with 10 mg/L of iron.
Starting Page	21
Ending Page	25
Page Count	5
File Format	PDF
ISSN	01634984
Journal	Biological Trace Element Research
Volume Number	150
Issue Number	1-3
e-ISSN	15590720
Language	English
Publisher	Humana Press Inc
Publisher Date	2012-07-03
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Zinc Iron Iron absorption Interaction Milk Humans Biochemistry Nutrition Biotechnology Oncology
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Inorganic Chemistry

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