NDLI: Effect of Dietary Selenium and Cancer Cell Xenograft on Peripheral T and B Lymphocytes in Adult Nude Mice

Content Provider	Springer Nature Link
Author	Cheng, Wen Hsing Holmstrom, Alexandra Li, Xiangdong Wu, Ryan T. Y. Zeng, Huawei Xiao, Zhengguo
Copyright Year	2011
Abstract	Selenium (Se) is known to regulate tumorigenesis and immunity at the nutritional and supranutritional levels. Because the immune system provides critical defenses against cancer and the athymic, immune-deficient NU/J nude mice are known to gradually develop CD8$^{+}$ and CD4$^{+}$ T cells, we investigated whether B and T cell maturation could be modulated by dietary Se and by tumorigenesis in nude mice. Fifteen homozygous nude mice were fed a Se-deficient, Torula yeast basal diet alone (Se−) or supplemented with 0.15 (Se+) or 1.0 (Se++) mg Se/kg (as Na$_{2}$SeO$_{4}$) for 6 months, followed by a 7-week time course of PC-3 prostate cancer cell xenograft (2 × 10$^{6}$ cells/site, 2 sites/mouse). Here, we show that peripheral B cell levels decreased in nude mice fed the Se − or Se++ diet and the CD4$^{+}$ T cell levels increased in mice fed the Se++ diet. During the PC-3 cell tumorigenesis, dietary Se status did not affect peripheral CD4$^{+}$ or CD8$^{+}$ T cells in nude mice whereas mice fed with the Se++ diet appeared to exhibit greater peripheral CD25$^{+}$CD4$^{+}$ T cells on day 9. Dietary Se status did not affect spleen weight in nude mice 7 weeks after the xenograft. Spleen weight was associated with frequency of peripheral CD4$^{+}$, but not CD8$^{+}$ T cells. Taken together, dietary Se at the nutritional and supranutritional levels regulates peripheral B and T cells in adult nude mice before and after xenograft with PC-3 prostate cancer cells.
Starting Page	230
Ending Page	235
Page Count	6
File Format	PDF
ISSN	01634984
Journal	Biological Trace Element Research
Volume Number	146
Issue Number	2
e-ISSN	15590720
Language	English
Publisher	Humana Press Inc
Publisher Date	2011-10-22
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Selenium Cancer T cell B cell Biochemistry Oncology Nutrition Biotechnology
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Inorganic Chemistry

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