NDLI: Antioxidant enzyme activities of human peripheral blood mononuclear cells exposed to trace elements

Content Provider	Springer Nature Link
Author	Kuppusamy, U. R. Dharmani, M. Kanthimathi, M. S. Indran, M.
Copyright Year	2005
Abstract	The trace elements copper, zinc, and selenium are important immune modulators and essential cofactors of the antioxidant enzymes. In the present study, the proliferative effect of human peripheral mononuclear cells (PBMCs) that have been exposed to copper, zinc, and selenium and the corresponding activities of antioxidant enzymes, namely superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase, were determined. Zinc and copper stimulated the PBMC proliferation in a dose-dependent manner within the dose range 25–200 μmol/L. SOD and GPx activities in PBMCs exposed to zinc were inhibited, whereas catalase activity was unaffected. All the three antioxidant enzymes in the cells exposed to copper were inhibited. Selenium exerted more potent inhibition of the cell proliferation while causing stimulation of the antioxidant enzymes at the lowest dose (25 μmol/L) than at the highest dose (200 μmol/L) tested. A significant negative correlation was observed between proliferation and antioxidant enzyme (SOD and GPx) activities in trace-element-exposed PBMC. The present findings substantiate the importance of trace elements as immune modulators and the involvement of enzymatic antioxidant system in the immune cell regulation.
Starting Page	29
Ending Page	39
Page Count	11
File Format	PDF
ISSN	01634984
Journal	Biological Trace Element Research
Volume Number	106
Issue Number	1
e-ISSN	15590720
Language	English
Publisher	Humana Press
Publisher Date	2005-01-01
Publisher Place	Totowa
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biochemistry Biotechnology Nutrition Oncology
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Inorganic Chemistry

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