NDLI: Kinetic Analysis and pH-Shift Control Strategy for Propionic Acid Production with Propionibacterium Freudenreichii CCTCC M207015

Content Provider	Springer Nature Link
Author	Feng, Xiaohai Xu, Hong Yao, Jun Li, Sha Zhu, Hongyang Ouyang, Pingkai
Copyright Year	2008
Abstract	The production of propionic acid by Propionibacterium freudenreichii CCTCC M207015 was investigated in a 7.5-l stirred-tank fermentor. Batch fermentations by P. freudenreichii CCTCC M207015 at various pH values ranging from 5.5 to 7.0 were studied. Based on the analysis of the time course of specific cell growth rate (μ $_{x}$) and specific propionic acid formation rate (μ $_{p}$), a two-stage pH-shift control strategy was proposed. At first 48 h, pH was controlled at 6.5 to obtain the maximal μ $_{x}$, subsequently pH 6.0 was used to maintain high μ $_{p}$ to enhance the production of propionic acid. By applying this pH-shift control strategy in propionic acid fermentation, the maximal propionic acid and glucose conversion efficiency had a significant improvement and reached 19.21 g/l and 48.03%, respectively, compared with those of constant pH operation (14.58 g/l and 36.45%). Fed-batch fermentation with pH-shift control strategy was also applied to produce propionic acid; the maximal propionic acid yield and glucose conversion efficiency reached 25.23 g/l and 47.76%, respectively.
Starting Page	343
Ending Page	349
Page Count	7
File Format	PDF
ISSN	02732289
Journal	Applied Biochemistry and Biotechnology
Volume Number	160
Issue Number	2
e-ISSN	15590291
Language	English
Publisher	Humana Press Inc
Publisher Date	2008-07-15
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Propionibacterium freudenreichii CCTCC M207015 Propionic acid Kinetic analysis pH-Shift Control Strategy Fed-batch fermentation Biochemistry Biotechnology
Content Type	Text
Resource Type	Article
Subject	Medicine Molecular Biology Environmental Engineering Biochemistry Bioengineering Applied Microbiology and Biotechnology Biotechnology

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