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| Content Provider | Springer Nature Link |
|---|---|
| Author | Werengowska Ciećwierz, Karolina Wiśniewski, Marek Terzyk, Artur P. Roszek, Katarzyna Czarnecka, Joanna Bolibok, Paulina Rychlicki, Gerhard |
| Copyright Year | 2015 |
| Abstract | We discuss eight major challenges in the field of carbon nanomaterial toxicity. Generally, we pick up some of them, and the most important challenge is searching of the qualitative relationships between nanofactors and cytotoxicity. This is important since it can provide the possibility of conscious changes of carbon nanotubes cytotoxicity by manipulation with selected nanofactors. Therefore, the toxicity of a series of gradually oxidized carbon nanotubes is studied. We show, for the first time, that toxicity of those materials depends strongly on the ratio of acidic to basic group concentration—the higher is this ratio value, the more toxic are nanotubes. In this way, by changing this ratio, one can change toxicity. This correlation is more evident after ultrasonication, and it is connected with the accessibility of charged groups for interactions with proteins. Toxicity also depends on the ability of nanotubes for protein adsorption. We suggest that the changes in the protein composition of medium, especially lack of important growth factors, inhibit cell proliferation. |
| Starting Page | 730 |
| Ending Page | 741 |
| Page Count | 12 |
| File Format | |
| ISSN | 02732289 |
| Journal | Applied Biochemistry and Biotechnology |
| Volume Number | 176 |
| Issue Number | 3 |
| e-ISSN | 15590291 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2015-04-18 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | CNT oxidation Ultrasonication CNT toxicity MSC cells CHO cells Biotechnology Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Molecular Biology Environmental Engineering Biochemistry Bioengineering Applied Microbiology and Biotechnology Biotechnology |
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