NDLI: Brugia malayi Thioredoxin Peroxidase as a Potential Vaccine Candidate Antigen for Lymphatic Filariasis

Content Provider	Springer Nature Link
Author	Anand, Setty Balakrishnan Rajagopal, Vasudevan Kaliraj, Perumal
Copyright Year	2012
Abstract	Attempts were made to evaluate the protective efficacy of Brugia malayi thioredoxin peroxidase (BmTPX) in a mouse model. Mice immunized with a protein vaccine containing rBmTPX developed higher titres (1:5,000/1:10,000) of anti-BmTPX antibodies, compared with the mice immunized with the alum control. There was a higher level of cellular proliferative response in mice immunized with BmTPX compared with the alum control (p < 0.05), which was associated with a Th2-type of response. In order to compare the prophylactic efficacy of BmTPX in natural infection, we evaluated the human immune responses to these antigens in endemic normals (EN) and infected individuals (microfilaraemic and chronic pathology). Results showed that EN subjects carry BmTPX-specific IgG1 and IgG3 circulating antibodies against natural exposure to filariasis. Peripheral blood mononuclear cells from EN subjects responded strongly to rBmTPX by proliferating, as well as by secreting interferon (IFN)-γ (Th1) and IL-5 (Th2), a mixed type of response to rBmTPX. In the case of infected individuals, there was no IFN-γ or IL-5 response. Thus, there was a clear dichotomy in the cytokine production by infected versus EN individuals. Our findings suggest that BmTPX may be a suitable antigen candidate for lymphatic filariasis, but a further study is still required.
Starting Page	1351
Ending Page	1364
Page Count	14
File Format	PDF
ISSN	02732289
Journal	Applied Biochemistry and Biotechnology
Volume Number	167
Issue Number	5
e-ISSN	15590291
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-04-24
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Filariasis Vaccines Brugia Thioredoxin peroxidase Antigens Biotechnology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Molecular Biology Environmental Engineering Biochemistry Bioengineering Applied Microbiology and Biotechnology Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Brugia malayi thioredoxin peroxidase as a potential vaccine candidate antigen for lymphatic filariasis.

Identification of 38kDa Brugia malayi microfilarial protease as a vaccine candidate for lymphatic filariasis

Brugia malayi Encode Stage-Specific Candidate Vaccine Antigens for Filariasis (2000)

Evaluation of immunoprophylactic efficacy of brugia malayi transglutaminase (bmtga) in single and multiple antigen vaccination with bmalt-2 and bmtpx.

Identification of 38kDa Brugia malayi microfilarial protease as a vaccine candidate for lymphatic filariasis.

Host protective immunity and vaccine development studies in lymphatic filariasis

Host protective immunity and vaccine development studies in lymphatic filariasis.

Production and single-step purification of Brugia malayi abundant larval transcript (ALT-2) using hydrophobic interaction chromatography

Evaluation Of Brugia Malayi Sheath Protein (Shp-1) As A Diagnostic Antigen For Human Lymphatic Filariasis

Brugia malayi Thioredoxin Peroxidase as a Potential Vaccine Candidate Antigen for Lymphatic Filariasis

Similar Documents

Brugia malayi thioredoxin peroxidase as a potential vaccine candidate antigen for lymphatic filariasis.

Identification of 38kDa Brugia malayi microfilarial protease as a vaccine candidate for lymphatic filariasis

Brugia malayi Encode Stage-Specific Candidate Vaccine Antigens for Filariasis (2000)

Evaluation of immunoprophylactic efficacy of brugia malayi transglutaminase (bmtga) in single and multiple antigen vaccination with bmalt-2 and bmtpx.

Identification of 38kDa Brugia malayi microfilarial protease as a vaccine candidate for lymphatic filariasis.

Host protective immunity and vaccine development studies in lymphatic filariasis

Host protective immunity and vaccine development studies in lymphatic filariasis.

Production and single-step purification of Brugia malayi abundant larval transcript (ALT-2) using hydrophobic interaction chromatography

Evaluation Of Brugia Malayi Sheath Protein (Shp-1) As A Diagnostic Antigen For Human Lymphatic Filariasis

Brugia malayi Thioredoxin Peroxidase as a Potential Vaccine Candidate Antigen for Lymphatic Filariasis