NDLI: The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility

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The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility

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The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility

Content Provider	Springer Nature Link
Author	Liu, X. Xu, J. Hu, C. D. Pan, Z. L. Zhang, Y. C.
Copyright Year	2014
Abstract	Toll-like receptors (TLRs) play an important role in the induction and regulation of the innate immune system or adaptive immune responses. Genetic variations within human TLRs have been reported to be associated with rheumatoid arthritis (RA). This study was conducted to investigate correlation between SNP of downstream mononucleotide in signal transduction of Toll-like receptors and predisposing genes of RA. There was obviously correlative between single nucleotide polymorphism and predisposing genes of RA. G-type of IL-1RAP rs766442 may be protecting genes of RA, while T-type alleles of IL-6R rs11265618 and IL-1RAP rs766442 may be susceptible genes of RA. In conclusion, the studies on the nucleis acid polymorphism in TLRs signal pathway contribute to disclose genes’ influence on the attack mechanism of RA, early diagnosis and treatment of RA.
Starting Page	155
Ending Page	159
Page Count	5
File Format	PDF
ISSN	00954527
Journal	Cytology and Genetics
Volume Number	48
Issue Number	3
e-ISSN	19349440
Language	English
Publisher	Allerton Press
Publisher Date	2014-06-14
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Rheumatoid arthritis Toll like receptors gene single nucleotide polymorphism Human Genetics
Content Type	Text
Resource Type	Article
Subject	Cell Biology Genetics Histology Agricultural and Biological Sciences Genetics (clinical)

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