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The pathogenetic importance of C774T single nucleotide polymorphism of the endothelial nitric oxide synthase gene in the development of metabolic syndrome

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Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 9

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 8

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 7

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 6

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 5

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 4

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 3

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 2

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 1

The pathogenetic importance of C774T single nucleotide polymorphism of the endothelial nitric oxide synthase gene in the development of metabolic syndrome

Content Provider	Springer Nature Link
Author	Fattakhov, N. S. Vasilenko, M. A. Skuratovskaia, D. A. Kulikov, D. I. Kirienkova, E. V. Zatolokin, P. A. Beletskaya, M. A. Litviva, L. S.
Copyright Year	2016
Abstract	The relationship between nitric oxide production and metabolic disorders and the role of endothelial nitric oxide synthase (eNOS or NOS3) in metabolic syndrome (MS) remain poorly understood and need deeper investigation. In this context the role of the NOS3 gene in pathogenesis of MS is of special interest. The aim of the study was to investigate association of NOS3 single nucleotide polymorphism C774T with risk of MS in the Slavic population of the Kaliningrad region and the relationship of this polymorphic variant with some parameters of endothelial dysfunction. The study included 128 patients (48 men and 80 women aged from 36 to 52 years) with MS. The control group consisted of 126 healthy volunteers (60 men and 66 women aged from 30 to 40 years). Genotyping was performed by real-time PCR. Serum nitrite levels were determined spectrophotometrically by the Griess method. Serum levels of endothelin-1 and eNOS were evaluated by ELISA. The study has shown association of T allele (OR = 2.06; p = 0.0004; CI: 1.38–3.08) and CT genotype (OR = 1.97; p = 0.014; CI: 1.14–3.40 ) C774T polymorphism of the NOS3 gene with risk of MS in the Slavic population of the Kaliningrad region. Allele C (OR = 0.48; p = 0.0004; CI: 0.32–0.72) and homozygous CC genotype (OR = 0.41; p = 0.001; CI: 0.24–0.69) C774T polymorphism of the NOS3 gene were associated with reduced risk of the development of MS. Significant differences in serum levels of eNOS and endothelin-1 depended on the CT and TT genotypes of C774T polymorphism of the NOS3 gene in MS.
Starting Page	81
Ending Page	86
Page Count	6
File Format	PDF
ISSN	19907508
Journal	Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
Volume Number	10
Issue Number	1
e-ISSN	19907516
Language	English
Publisher	Pleiades Publishing
Publisher Date	2016-03-23
Publisher Place	Moscow
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	metabolic syndrome nitric oxide endothelial NO synthase single nucleotide polymorphism C774T Bioorganic Chemistry Medicinal Chemistry
Content Type	Text
Resource Type	Article
Subject	Biochemistry Clinical Biochemistry Molecular Medicine

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