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Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 5, Issue 2, June 2011

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 5, Issue 1, March 2011

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 4

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 3

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 2

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 1

Molecular forms of adiponectin: Comparative evaluation of their correlations with parameters of carbohydrate and lipid metabolism

Content Provider	Springer Nature Link
Author	Tanyanskiy, D. A. Denisenko, A. D.
Copyright Year	2011
Abstract	Interrelationship between total, multimer (MM) and oligomer (OM) adiponectin blood concentrations with some metabolic parameters has been investigated in 49 men and 49 women (mean age of 57.3 ± 10.1 years). We have found negative correlations between total blood adiponectin and its MM form content with body mass index, waist circumference, the insulin resistance index HOMA, with blood concentrations of insulin, glucose, free fatty acids, triglycerides and also positive correlations with high density lipoprotein cholesterol content. There was a poor correlation between OM adiponectin concentration with any parameter studied. According to the regression analysis, concentration of total adiponectin but not its MM form was an independent determinant of the HOMA index in women and free fatty acid concentration in men. In the group of men with the low level of adiponectin its MM form but not total adiponectin reversely correlated with the HOMA index and was its independent determinant. Thus, correlation between blood adiponectin concentration and metabolic parameters is associated with its MM rather than OM form. Study of the role of adiponectin in development of metabolic disorders may be limited to determination of total blood adiponectin concentration except a group of male patients characterized by a low level of this adipokine. In these patients concentrations of the MM form should be determined.
Starting Page	293
Ending Page	300
Page Count	8
File Format	PDF
ISSN	19907508
Journal	Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
Volume Number	5
Issue Number	3
e-ISSN	19907516
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2011-08-18
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	adiponectin insulin resistance metabolic syndrome Medicinal Chemistry Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Biochemistry Clinical Biochemistry Molecular Medicine

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