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| Content Provider | Springer Nature Link |
|---|---|
| Author | Fadeev, R. S. Solovieva, M. E. Slyadovskiy, D. A. Zakharov, S. G. Fadeeva, I. S. Setov, A. S. Dolgikh, N. V. Golenkov, A. K. Akatov, V. S. |
| Copyright Year | 2015 |
| Abstract | One of the major causes of low efficiency of the therapy for acute myeloid leukemia is drug resistance of leukemic cells. Microenvironment plays a key role in formation of the phenotype of leukemic cell drug resistance. Investigation of the mechanisms of microenvironment-mediated drug resistance is important to identify novel pharmacological targets for the acute myeloid leukemia therapy. We studied the role of cell aggregation in the drug resistance of leukemic cells. We showed the increased resistance of acute myeloid leukemia cells THP-1 to bortezomib, doxorubicin and fludarabine in multicellular aggregates. In the multicellular aggregates of THP-1 with the higher drug resistance, cell proliferation activity did not change, while the intracellular level of anti-apoptotic protein Bcl-2 increased. Inhibition of the aggregation of THP-1 cells prevented drug resistance. This work demonstrates the involvement of cell aggregation in the formation of drug resistance phenotype in leukemic cells. |
| Starting Page | 135 |
| Ending Page | 143 |
| Page Count | 9 |
| File Format | |
| ISSN | 19907478 |
| Journal | Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology |
| Volume Number | 9 |
| Issue Number | 2 |
| e-ISSN | 19907494 |
| Language | English |
| Publisher | Pleiades Publishing |
| Publisher Date | 2015-06-17 |
| Publisher Place | Moscow |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | acute myeloid leukemia drug resistance intercellular adhesion multicellular aggregates Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Biophysics |
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