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  1. Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology
  2. Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 9
  3. Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 9, Issue 2, April 2015
  4. Cell aggregation increases drug resistance of acute myeloid leukemia cells
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Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 11
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 10
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 9
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 9, Issue 4, October 2015
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 9, Issue 3, July 2015
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 9, Issue 2, April 2015
Membrane fusion. Two possible mechanisms underlying a decrease in the fusion energy barrier in the presence of fusion proteins
Simple model of local ordering of DPPC lipids in contact with cholesterol
Effects of pH on the adsorption of the viral matrix protein M1
Electrogenic binding of ions at the cytoplasmic side of the Na$^{+}$,K$^{+}$-ATPase
Specificity of interactions of the surface-active protonophore 2,4,6-trichloro-3-pentadecylphenol with artificial and mitochondrial membranes
Malonate as an inhibitor of cyclosporine A-sensitive calcium-independent free oxidation in liver mitochondria induced by fatty acids
Effect of melatonin on stress-induced opening of non-selective pore in mitochondria from brain of young and old rats
Alterations in adenylyl cyclase sensitivity to hormones in the brain, myocardium, and testes of rats immunized with BSA-conjugated peptide 269–280 of type 3 melanocortin receptor
Cell aggregation increases drug resistance of acute myeloid leukemia cells
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 9, Issue 1, January 2015
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 8
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 7
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 6
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 5
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 4
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 3
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 2
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 1

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Cell aggregation increases drug resistance of acute myeloid leukemia cells

Content Provider Springer Nature Link
Author Fadeev, R. S. Solovieva, M. E. Slyadovskiy, D. A. Zakharov, S. G. Fadeeva, I. S. Setov, A. S. Dolgikh, N. V. Golenkov, A. K. Akatov, V. S.
Copyright Year 2015
Abstract One of the major causes of low efficiency of the therapy for acute myeloid leukemia is drug resistance of leukemic cells. Microenvironment plays a key role in formation of the phenotype of leukemic cell drug resistance. Investigation of the mechanisms of microenvironment-mediated drug resistance is important to identify novel pharmacological targets for the acute myeloid leukemia therapy. We studied the role of cell aggregation in the drug resistance of leukemic cells. We showed the increased resistance of acute myeloid leukemia cells THP-1 to bortezomib, doxorubicin and fludarabine in multicellular aggregates. In the multicellular aggregates of THP-1 with the higher drug resistance, cell proliferation activity did not change, while the intracellular level of anti-apoptotic protein Bcl-2 increased. Inhibition of the aggregation of THP-1 cells prevented drug resistance. This work demonstrates the involvement of cell aggregation in the formation of drug resistance phenotype in leukemic cells.
Starting Page 135
Ending Page 143
Page Count 9
File Format PDF
ISSN 19907478
Journal Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology
Volume Number 9
Issue Number 2
e-ISSN 19907494
Language English
Publisher Pleiades Publishing
Publisher Date 2015-06-17
Publisher Place Moscow
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword acute myeloid leukemia drug resistance intercellular adhesion multicellular aggregates Cell Biology
Content Type Text
Resource Type Article
Subject Cell Biology Biochemistry Biophysics
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