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  1. Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology
  2. Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 7
  3. Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 7, Issue 1, January 2013
  4. Effects of extracellular YB-1 protein on cultured cells of human breast cancer
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Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 11
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 10
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 9
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 8
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 7
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 7, Issue 4, October 2013
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 7, Issue 3, July 2013
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 7, Issue 2, April 2013
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 7, Issue 1, January 2013
Microdomain-forming proteins of different families in common signal pathways
Interaction of liposomes bearing a lipophilic doxorubicin prodrug with tumor cells
Effects of extracellular YB-1 protein on cultured cells of human breast cancer
Resistance of cancer cells to the TRAIL-induced apoptosis in confluent cultures
Blockade of GABA$_{A}$ receptor channels by niflumic acid prevents agonist dissociation
Serotoninergic agonists and antagonists are the modulators of α$_{1}$-Adrenoceptor activity in rat brain cortical membranes
Hydrogen sulfide in regulation of frog myocardium contractility
The features of activation of free oxidation by α,ω-tetradecanedioic acid in liver mitochondria
Changes of the antenna of photosystem I induced by short-term heating
Molecular dynamics simulation of interaction between phospholipid membrane and pyrazine and its derivatives
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 6
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 5
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 4
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 3
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 2
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology : Volume 1

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Effects of extracellular YB-1 protein on cultured cells of human breast cancer

Content Provider Springer Nature Link
Author Moiseeva, N. I. Stromskaya, T. P. Rybalkina, E. Yu. Vaiman, A. V. Malyshkina, M. A. Kim, E. R. Eliseeva, I. A. Kulakovskiy, I. V. Ovchinnikov, L. P. Stavrovskaya, A. A.
Copyright Year 2013
Abstract Multifunctional protein YB-1, which takes a part in many DNA/RNA-associated events in cells (transcription, mRNA translation, splicing) is a promising prognostic and predictive marker for various human tumors. Recently it was discovered that protein YB-1 secreted by cells functions as an extracellular mitogen. These results were obtained on kidney mesangial cells and monocytes. Here we studied the effects of extracellular YB-1 on the cell number, migration and gene expression in the populations of three lines of human malignant breast cells (MCF-7, HBL-100, BT-474). We used recombinant full-length protein YB-1, which retained all the functional sites necessary for its various activities, including binding to the receptor Notch-3 (rYB-1). Extracellular rYB-1 increased the number of cells 2- to 3-fold in the tested lines. The wound was made in cell monolayers of HBL-100, MCF-7 and MCF-7/ras. Protein rYB-1 increased the rate of wound healing in MCF-7/ras. Sensitivity to chemotherapeutic agents did not change in the presence of rYB-1 in any of the cell lines studied. We have used expression microarrays to study the effects of rYB-1 on the profile of gene expression in MCF-7 cells and in MCF-7 cells transfected with YB-1-GFP construct. In MCF-7 cells extracellular rYB-1 mainly down-regulated different genes, while in the cells transfected with cDNA of YB-1-GFP the activity of different genes was up-regulated. Our results show that extracellular YB-1 protein and intracellular YB-1 produce diverse changes in the cells of mammary tumors. It is possible that extracellular YB-1 is involved in the regulation of cell proliferation and migration in the metastatic niche.
Starting Page 21
Ending Page 28
Page Count 8
File Format PDF
ISSN 19907478
Journal Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology
Volume Number 7
Issue Number 1
e-ISSN 19907494
Language English
Publisher SP MAIK Nauka/Interperiodica
Publisher Date 2013-02-26
Publisher Place Dordrecht
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword extracellular protein YB-1 biochip breast cancer Cell Biology
Content Type Text
Resource Type Article
Subject Cell Biology Biochemistry Biophysics
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