NDLI: The energy-corrective and antioxidative effect of cytoflavin in the postischemical period of human dermal fibroblasts in vitro

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The energy-corrective and antioxidative effect of cytoflavin in the postischemical period of human dermal fibroblasts in vitro

Content Provider	Springer Nature Link
Author	Tiuriaeva, I. I. Kurava, M. L. Gonchar, I. V. Rozav, Yu. M.
Copyright Year	2012
Abstract	The effect of the metabolic drug Cytoflavin (CF) with antihypoxic and antioxidative properties on human dermal fibroblasts in the model of ischemia/reoxygenation in vitro was studied. It was revealed that, during the reoxygenation period after ischemia, the cell death rate in culture with CF appeared to be 2–2.7 times lower than in control cultures. Recovery of ATP synthesis after ischemia was 2.1 times faster in culture with CF. The drug effectively reduced the level of reactive oxygen species (ROS) in fibroblasts after H$_{2}$O$_{2}$ treatment, which allowed their survival to be maintained at the level of control cells. Pretreatment of cells with CF for one day ensured the maintenance of a normal level of ROS during the investigated time period in fibroblasts subjected to H$_{2}$O$_{2}$ treatment and reduced H$_{2}$O$_{2}$-induced cell death by almost one-third as compared to non-pretreatment control cells. Addition of CF into the culture medium in the postischemic period showed no effect on Hsp70 synthesis, but led to a decrease in GRP78 synthesis, raised after ischemia, to the control level, indicating a resolution of unfolded protein response in these cells and normalization of the functioning of their endoplasmic reticulum.
Starting Page	367
Ending Page	375
Page Count	9
File Format	PDF
ISSN	1990519X
Journal	Cell and Tissue Biology
Volume Number	6
Issue Number	4
e-ISSN	19905203
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2012-08-15
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	dermal fibroblasts cytoflavin ischemia/reoxygenation reactive oxygen species ROS Hsp70 GRP78 Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology

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